Mice were housed separately by sex in groups of 1–5 mice/cage under a 14:10 light:dark cycle with controlled temperature and 35% humidity with ad libitum access to food (6% fat diet) and water. All mice were at least 87.5% C57BL/6J with the remaining background inferred as C57BL/...
A one- or two-way ANOVA followed by Sidak’s or Dunnett’s multiple comparison tests were used where appropriate when the mean values of more than three groups were compared. P-values of <0.05 were defined as significant. All statistical analyses were performed and visualized by GraphPad Prism...
we observe less pre-miRs in cells expressing mutant DGCR8 and that heme-dependent miRs are more sensitive to the loss of heme compared to the heme-independent miR. Therefore, heme dependence varies among different miRs both in vitro and in cells and is an intrinsic property encoded into each ...
Down, the path you can see Go down this path; and turn left / right at the first crossing. 语法构词法 (Word formation): 1. 合成法 (Compounding): watermelon, kind-hearted, downtown, life-size, handsome, hardworking, ice cream 2. 派生法 (Derivation): 前缀:supermarket, disagree, ...
preventing it from inhibiting heme synthesis. Note that inB. japonicum, no compartmentalization of nucleus, cytosol and mitochondrion exist. In mammals, the HO enzymes break down heme into biliverdin, CO and Fe2+. Biliverdin is then converted to bilirubin by biliverdin reductase....
Differences between groups were tested for statistical significance using the one-way ANOVA followed by Tukey’s post hoc test when more than two groups were analyzed or the unpaired 2-tailed Student’s t-test for the comparison of two groups (Figure 4A) p < 0.05 was considered significant. ...
Differences between groups were assessed using an analysis of variance followed by ANOVA-Tukey’s test, and p < 0.05 was considered to indicate a statistically significant difference. 3. Results 3.1. Glutathione Inhibits H2O2-Induced Cytotoxicity in RAW 264.7 Cells To establish the experimental ...