While heme catabolism by heme oxygenase-1 (HO-1) prevents programmed cell death, this cytoprotective effect requires the co-expression of ferritin H (heart/heavy) chain (FTH), which controls the pro-oxidant effect of labile Fe released from the protoporphyrin IX ring of heme. This antioxidant ...
Twitter Google Share on Facebook heme Thesaurus Medical Acronyms Encyclopedia Wikipedia Related to heme:heme protein,Heme iron,Heme oxygenase (hēm) n. A deep red, iron-containing compound, C34H32FeN4O4,that constitutes the nonprotein component of hemoglobin and certain other proteins. ...
Iron can be stored in the form of ferritin (FTN), or exported out of the cell by ferroportin (FPN) for the incorporation into new red blood cells during erythropoiesis [16]. Heme oxygenase's structure has a helical fold which traps heme between two helices, the proximal of which provides...
The latter can be effectively controlled by ferritin via sequestration and ferroxidase activity. These homeostatic adjustments have been shown to be effective in the protection of endothelium against the damaging effects of heme and oxidants; lack of adaptation in an iron-rich environment led to ...
Heme Oxygenase Induction Suppresses Hepatic Hepcidin and Rescues Ferroportin and Ferritin Expression in Obese Mice These interactions can change the conformations of Tg-Hbs, in particular the active center (i.e., the heme pocket), resulting in the loss of peroxidase activity. Hemoglobins Likely Funct...
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Heme oxygenase protects cells from heme-induced oxidative stress by generating beneficial molecules like carbon monoxide (CO), bilirubin, and ferritin. Indeed, HO-1 induction is accompanied by increased ferritin synthesis, scavenging of free iron and, subsequently, protection against its adverse effects...
HO-1 induction is assumed to confer cellular protection owing to the reduced presence of pro-oxidant heme, elevated levels of the antioxidant bilirubin [150], and the stimulation of ferritin production, which facilitates swift iron containment [151]. Additionally, HO might contribute to the decrease...
It makes use of iron, possibly delivered by mitochondrial ferritin to synthesize ISC, also distributed among several of the mitochondrial proteins (including several membrane-bound respiratory chain components: complexes I, II, and III and the matrix-soluble aconitase). In addition to its role in ...