The bulk of this chapter focuses on a wide variety of heme proteins with different functions. The heme-containing proteins to be discussed include: iron uptake and storage proteins (HasA and bacterioferritin), proteins in charge of transport and storage of oxygen (hemoglobin and myoglobin), ...
As such, pathogenic bacteria have evolved numerous sophisticated mechanisms whereby they utilize the host's heme containing proteins as a source of iron. In... A Wilks,KA Burkhard - 《Cheminform》 被引量: 197发表: 2007年 Macrophages sense and kill bacteria through carbon monoxide-dependent inflamm...
Peptide sequencing revealed the presence of several proteins including the heme-containing proteins (HCPs) hemoglobin, cytochrome c, and myoglobin. The loss of HCPs from thick sections to PBS corresponded with the blanching of the previously mottled INF within each section. HPLC analysis of these ...
It is concluded that heme and heme-containing proteins in erythrocyte are largely responsible for reducing artemisinin effectiveness and may contribute to resistance of Plasmodium falciparum infecting α-thalassemic erythrocytes observed in vitro. 展开 ...
Note, peroxidase or enzymatic activity of heme-containing proteins is determined by the axial ligands coordination of heme Fe (III) atom27,28,29. A lower-peroxidase activity is expected to occur where Fe (III) of heme is strongly ligated to the axial ligands. On the other hand, a higher ...
In this type of bacteria, a high expression of iron- or heme-containing proteins is required to promote nitrogen fixation. The nitrogenase complex, which comprises more than 10% 1Department of Chemistry, Faculty of Science, Hokkaido University, Sapporo 060-0810, Japan. 2Department of Molecular ...
Heme proteins, that is, proteins containing one or several heme groups, are of immense importance for life on earth (Chapman, Daff, & Munro, 1997). They function in a plethora of fundamental cellular processes such as storage and transport of gaseous molecules (e.g., globins), energy ...
Although several researchers, including Keilin and Hartree (1951), have pointed out remarkable similarities between annelid and vertebrate heme-containing respiratory proteins and recommended that they all be referred to as hemoglobins, nonvertebrate hemoglobins, especially the extracellular ones, did not...
Here, we consider the therapeutically important case of heme proteins featuring an iron core at the active site. Using a standard docking protocol, where the iron-ligand interaction is underestimated, we obtained a success rate of 28% for a test set of 50 heme-containing complexes with iron-...
Haem-containing proteins such as haemoglobin and myoglobin play an essential role in oxygen transport and storage. Comparison of the amino-acid sequences o... S Hou,RW Larsen,D Boudko,... - 《Nature》 被引量: 491发表: 2000年 A haemoprotein with kinase activity encoded by the oxygen senso...