Hematopoietic Embryonic Stem Cells HSC Derivatives HSC Location
Enhancing hematopoietic stem cell transplantation efficacy by mitigating oxygen shock. Cell 2015; 161: 1553–1565. 7. Simsek T, Kocabas F, Zheng J, Deberardinis RJ, Mahmoud AI, Olson EN et al. The distinct metabolic profile of hematopoietic stem cells reflects their location in a hypoxic niche...
The availability of ES cells from the human might make it possible to produce specific differentiated cell types for replacement cell therapies to treat a host of degenerative diseases. Stem cells from the embryo have fundamentally distinct properties when compared to stem cells from somatic tissues ...
Hematopoietic stem cells are capable of extensive self-renewal and expansion, particularly during embryonic growth. Although the molecular mechanisms involved with stem cell maintenance remain mysterious, it is now clear that an intraembryonic location, the aorta-gonad-mesonephros (AGM) region, is a si...
Hematopoietic stem cells(HSCs) are the key elements responsible for maintainingblood cell formationthroughout life.HSCsproliferate and differentiate in the hematopoietic organs (fetal liver, bone marrow,thymusand, more transiently, the spleen), which provide the environmental factors required for self-rene...
Hematopoietic stem cells (HSCs) are so rare that it’s difficult to comprehensively localize dividing and non-dividing HSCs. Thus, there has controversy about their specific location in the bone marrow. A recent Nature publication reported that the HSCs resides mainly in perisinusoidal niches through...
Stem cells present in this niche directly interact with the thin layer of bone lining cells in the medullary cavity of a bone. Specialized anatomical location in the bone marrow where hematopoietic stem cells receive extracellular signals for maintenance. It could be in the form of soluble ...
Keisuke Ito et al. uncover a new pathway regulating hematopoietic stem cell maintenance and function. In this pathway, the promyelocytic leukemia protein (PML) regulates the activity of the PPAR-δ nuclear hormone receptor and, thereby, fatty acid oxidat
Hematopoietic stem cells (HSCs) have the ability to self-renew and give rise to all lineages of blood cells. HSCs reside in niches that are local tissue microenvironments that maintain and regulate them. Although much progress has been made in elucidating the location and cellular components of ...
Olivier Herault8,9, Eric Solary1, William Vainchenker1, Virginie Joulin1, Fawzia Louache1,9,†, & Monika Wittner1,9,† Hematopoietic stem cells (HSCs) undergo self-renewal to maintain hematopoietic homeostasis for lifetime, which is regulated by the bone marrow (BM) microen...