Hematopoietic stem and progenitor cells (HSPCs) are located in the bone marrow in close association with a highly organized 3-dimensional structure formed by stroma cells, referred to as the niche. Mobilization of HSPCs from bone marrow to peripheral blood in response to granulocyte colony-...
Increased hematopoietic stem cell mobilization in aged mice Hematopoietic stem and progenitor cells (HSPCs) are located in the bone marrow in close association with a highly organized 3-dimensional structure formed ... Z Xing,MA Ryan,D Daria,... - 《Blood》 被引量: 286发表: 2006年 加载更多...
The spatial organization of hematopoietic cells in a co-culture is comparable to their distribution in bone marrow: based on a state of resting or active prolif- eration, cells are located in areas with different oxy- gen levels and nutrients availability. It was assumed ...
Hematopoietic stem cells (HSCs) located in adult bone marrow or fetal liver in mammals produce all cells from the blood system. At the top of the hierarchy are long-term HSCs endowed with lifelong self-renewal and differentiation properties. These features are controlled through key microenvironmenta...
researchers established that mature blood cells are formed from a rare population of hematopoietic stem cells (HSCs), which are located in the bone marrow. The development of molecular biology methods and their combination with classical physiological ones allowed a breakthrough in understanding the str...
We therefore aimed to analyze the allogenicity of recipient DCs afterin vivo3pRNA treatment andin vivoconditioning therapy. On day 3 after allo-HSCT, high amounts of transplanted donor T cells are located within the spleen of recipient mice, before they begin to infiltrate GVHD effector organs ...
Ontogeny-related changes in proliferative potential of human hematopoietic cells. Blood cells originate from hematopoietic stem cells that are located at different sites during ontogeny. Production of human stem cells and their progeny i... Lansdorp,M P. - 《Journal of Experimental Medicine》 被引量...
In subject area: Immunology and Microbiology Hematopoietic stem cells (HSCs) are cells that are capable of self-renewal and differentiating into all hematopoietic lineages over the lifetime of an organism. From: Developmental & Comparative Immunology, 2016 ...
Because several studies suggested that morphologically defined hematopoietic stem/progenitor cells in the AGM region appeared to be attached in clusters to the ventrally located endothelium of the dorsal aorta, we derived cell lines from this intraembryonic site using an anti-CD34 antibody to select ...
Note that c-kit+ cells are located in the near sinusoids and these cells did not express MFG-E8. S, sinusoid. Enlarged images of the boxed region are shown in the upper right corner of each panel. (b) Expression of MFG-E8 in F4/80+ macrophages in the bone marrow of adult mice. ...