Present disclose provides the methods for gene therapy to utilize candidate stem cell, lymphoid progenitor cell and/or myeloid progenitor. Differentiation to provide the gene of the expression of cell transgenosis, after cell in this regard and their offspring. In a preferred embodiment, cell ...
The present disclosure provides methods for gene therapy utilizing hematopoictic stem cells, lymphoid progenitor cells, and/or myeloid progenitor cells. The cells are genetically modified to provide a gene that is expressed in these cells and their progeny after differentiation. In one embodiment the...
Hematopoietic stem cell gene therapy: progress toward therapeutic targets. Bone Marrow Transplant. 2003;32:1–7. CAS PubMed Google Scholar Laufs S, Buss EC, Zeller WJ, et al. Transfer of drug resistance genes in hematopoietic progenitors for chemoprotection: is it still an option? Drug ...
The present invention provides the use of hematopoietic stem cells (HSC), lymphoid progenitor cells and / or bone marrow progenitor cells for gene therapy approach. 这些细胞通过基因重组产生能够在这些细胞及其分化后的后代细胞中表达的基因. These cells produce gene capable of expression in these cells ...
Hematopoietic Stem Cell Therapy. 来自 Semantic Scholar 喜欢 0 阅读量: 37 作者: CI Civin 摘要: In utero hematopoietic stem cell transplantation (IUHSCTx) is a promising approach for the treatment of a potentially large number of fetuses affected by congenital hematologic disorders. With technical ...
Therefore, the results suggest that the cells, known as mesenchymal stem cells or marrow stromal cells, can be used for both cell and gene therapy of ... DJ Prockop - 《Matrix Biology Journal of the International Society for Matrix Biology》 被引量: 202发表: 1998年 Engraftment of bone mar...
Hematopoietic stem cell (HSC) gene therapy remains a highly attractive treatment option for many disorders, including hematologic conditions, immunodeficiencies including human immunodeficiency virus (HIV)/acquired immune deficiency syndrome (AIDS), and other genetic disorders such as lysosomal storage disease...
- 《Gene Therapy》 被引量: 66发表: 2000年 Transforming Growth Factor-Beta Superfamily in Mouse Embryonic Stem Cell Self-Renewal Embryonic stem (ES) cells are pluripotent cells that maintain the capability of undifferentiated self-renewal in culture. As mouse ES cells have the capaci... KE ...
cell. Hematopoietic stem cells are self-renewing and multi-directional, it is never depleted during normal hematopoietic in the body, and it can maintain the relative stability of genomic DNA during differentiation, thus becoming an ideal target cell for gene therapy of certain diseases. The ...
摘要: Gene therapy is recently becoming a therapeutic option for patients affected by LSDs, and new clinical trials are starting worldwide. The state of the development of hematopoietic stem cell gene theraDOI: 10.1007/978-1-4614-8357-1_5 年份: 2013 ...