Signals from BM niches not only control HSC dormancy, but also regulate the balance between self-renewal and differentiation. In the future, successful expansion of HSCs for therapeutic use will require three-dimensional reconstruction of a stem cell-niche unit....
types of niches essential for HSC maintenance, an endosteal niche and vascular niches, have been identified and characterized, mainly in the murine bone marrow[4–6]. However, it is still an unsettled issue as to which niche harbors the quiescent long-term repopulating hematopoietic stem ...
Niches for hematopoietic stem cells and immune cell progenitors Bone marrow niche cells have been reported to fine-tune hematopoietic stem cell (HSC) stemness via direct interaction or secreted components. Nevertheless,... T Sugiyama,Y Omatsu,T Nagasawa - Int Immunol 被引量: 0发表: 2019年 Compa...
Molecules including N-cadherin, Notch-1, Tie2, and CXCR-4 are implicated in the HSC-to-niche interface. The identification and purification of long-term (LT)-HSCs relies on combinations of cell surface markers, with the presence or absence of specific antigens allowing discrimination of these ...
Self-renewal and multidirectional differentiation of hematopoietic stem cells (HSCs) are strictly regulated by numerous cellular components and cytokines in the bone marrow (BM) microenvironment. Several cell types that regulate HSC niche have been identified, including both non-hematopoietic cells and HSC...
Objective To observe the differentiation of human hemopoietic stem cells after bone marrow mesenchymal stem cells (MSCs) through modeling porcine hemopoietic microenvironment in vitro. 目的研究猪造血微环境对人造血干细胞(HSC)向红系分化的影响。 更多例句>> 4...
Human prostate cancer metastases target the hematopoietic stem cell niche to establish footholds in mouse bone marrow HSC homing, quiescence, and self-renewal depend on the bone marrow HSC niche. A large proportion of solid tumor metastases are bone metastases, known to us... Y Shiozawa,EA Ped...
Background: Hematopoietic stem cell (HSC) niche of the BM provides a specialized microenvironment for the regulation of HSCs. The strict control of HSCs by the niche coordinates the balance between the proliferation and the differentiation of HSCs for the homeostasis of the blood system in steady ...
Homing and mobilization in the stem cell niche All mature blood cells are derived from the haemopoietic stem cell (HSC). In common with all other haemopoietic cells, stem cells are mobile, and it is thi... AD Whetton,GJ Graham - 《Trends in Cell Biology》 被引量: 650发表: 1999年 Mobil...
1、(P1)Multipotent stromal cells (MSCs) and their osteoblastic lineage cell (OBC) derivatives are part of the bone marrow (BM) niche and contribute to hematopoietic stem cell (HSC) maintenance. Here, we show that myeloproliferative neoplasia (MPN) progressively remodels the endosteal BM niche int...