However, murine hematopoietic stem cells were reported to be CD34. We have characterized the surface phenotypes of murine hematopoietic stem cells by using a murine transplantation model. Our studies revealed that the majority of the stem cells in normal adult mice are CD34 while a minority (15%...
Hematopoietic stem cells (HSCs) in the endosteum of mesoderm-derived appendicular bones have been extensively studied. Neural crest-derived bones differ from appendicular bones in developmental origin, mode of bone formation and pathological bone resorpt
vascular cells, adipocytes, osteoblasts and osteoclasts, as weft as mesenchymal stem cells and hematopoietic stem cells, it was previously thought that cells within bone marrow solely functioned to regenerate cells within the marrow, as well as aft circulating hematopoietic cells in peripheral blood. ...
Hematopoietic stem cells are multipotent, myelolymphoid stem cells, which serve as a source of hematopoietic cells. Notes In human, HSC from the fetal liver colonize the bone marrow during the sixth month. These precursors are Lin- (lineage-negative), meaning that they lack detectable surfac...
Osteoblasts influence stem cell numbers in the bone marrow. Hematopoietic stem cells also locate preferentially in perivascular regions. Real-time imaging traced the homing of purified hematopoietic stem cells after transplantation and showed that these cells preferentially colonize the endosteal zone, an ...
Hematopoietic stem cellsBone marrow nicheMesenchymal stem cellsHematopoietic stem cells (HSCs) reside in a milieu that supports their functions, differentiation, and survival. This niche consists of several types of cells, including mesenchymal stem/stromal cells, endothelial cells, osteoblasts, ...
Cues extrinsic to stem cells, emanating from the surrounding microenvironment or niche, are important in the maintenance of stem cell self-renewal and differentiation capacity. The existence of a stem cell niche has been demonstrated for a variety of stem cell populations in diverse organisms. The ...
www.nature.com/cddis ARTICLE OPEN Mdm2/p53 levels in bone marrow mesenchymal stromal cells are essential for maintaining the hematopoietic niche in response to DNA damage Rasoul Pourebrahim 1,4, Rafael Heinz Montoya1,4, Zoe Alaniz1, Lauren Ostermann 1, Patrick P. Lin2, Bin Liu3, Edward ...
Hematopoietic stem cells (HSCs) are responsible for the production of mature blood cells in bone marrow; peripheral pancytopenia is a common clinical presentation resulting from several different conditions, including hematological or extra-hematological diseases (mostly cancers) affecting the marrow function...
5) Bone marrow hemopietic stem/progenitor cells 骨髓造血干/祖细胞 6) Blood cells in bone marrow 骨髓血细胞 补充资料:造血细胞生长因子 分子式: CAS号: 性质:足指一类促使造血干细胞分化的生长因子。如SCF,G-CSF,M-CSF,GM-CSF,EPO,TPO等。