Hematopoiesis is the body's way of making the cellular constituents of blood. Oxygen transport, response to infections, and control of bleeding are among the functions of different mature blood cells. These specific functions are acquired as cells mature in the bone marrow. Stem cells are the "...
One uses 'targeting-induced local lesions in genomes' (TILLING), a process by which random mutagenesis and individual exon sequencing are carried out to identify mutations within a particular gene, essentially mimicking the outcome of targeted mutagenesis [24]. This approach has led to the ...
Hematopoiesis is the process of blood cell formation that occurs primarily in the bone marrow, which involves the differentiation of hematopoietic stem cells (HSCs) into various types of blood cells, including erythrocytes, leukocytes, and platelets. Recent evidence increasingly highlights the importance ...
Mitochondrial metabolism is a tightly regulated process that plays a central role throughout the lifespan of hematopoietic cells. Herein, we analyze the consequences of the mitochondrial oxidative phosphorylation (OXPHOS)/metabolism disorder associated with the cell-specific hematopoietic ablation of apoptosis...
Cancer development is a complex process driven by inherited and acquired molecular and cellular alterations. Prevention is the holy grail of cancer elimination, but making this a reality will take a fundamental rethinking and deep unders... A Spira,MB Yurgelun,L Alexandrov,... - 《Cancer Resear...
There is an ongoing shift in demographics such that older persons will out number young persons in the coming years, and with it age-associated tissue attrition and increased diseases and disorders. There has been an increased influx in literature on the association of the aging process with ...
Our goal was to use a compilation of methods and evidence to specify loci with high functional likelihood. Some models have been previously developed to identify active genomic loci (e.g., CADD [29], GWAVA [17], and DeepSEA [28]). We compared the effectiveness of these models, and our ...
Considering that expression of YS68 in the hematocyte of CD34 positive cells, which are thought to be a group of relatively immature hematocytes (Example 6), is strong, YS68 is suggested to function in the process of differentiation from hemangioblasts to hematocytes. The “YS68” proteins...
Hematopoiesis is a complex process beginning with an uncommitted pluripotent hematopoietic stem cell capable to reconstitute the entire blood and immune systems. Despite extensive research, not all of the regulatory processes of hematopoietic stem cell proliferation and commitment are identified and fully ...
In this study, hematopoiesis was examined in 18 healthy elderly subjects with unexplained anemia and in 15 young and 15 healthy elderly individuals without anemia. No reduction in circulating testosterone was noted, making decreased androgen levels as a cause for the anemia unlikely. The 2,3 ...