Orca-Q Has Early Activity, Tolerability in Haplo-SCT Population Gina Mauro December 13th 2023 Investigators of a phase 1 trial identify no safety signals with Orca-Q in the haploidentical stem cell transplantation setting. Tafasitamab Quadruplet Appears Safe, Feasible in Newly Diagnosed DLBCL ...
We performed VIPER (Virtual Inference of Protein-activity by Enriched Regulon) analysis in order to suggest transcription factor (TF) activity in AML progenitor cells [41]. It uses the expression of genes that are regulated by a given TF as an accurate reporter of its activity. Among the top...
Disease-Modifying Potential of BET Inhibitor Pelabresib (CPI-0610) as Demonstrated by Improvements in Bone Marrow Function and Clinical Activity in Patients With Myelofibrosis - Preliminary Data Srdan Verstovsek, Mohamed E....
With blocking of PRL-3 (right), STAT6 activity is reduced. L1236 cells do not possess the ability to increase IL-13 secretion and proliferation is reduced. HDLM2 cells can increase IL-13 secretion followed by an increase of pSTAT6 and thereby maintain cell growth Full size image...
When compared with a large panel of murine monoclonal antibodies that specifically bound to human CD38, isatuximab was the only antibody with potent apoptotic activity in the absence of crosslinking agents [21]. This ability was confirmed in studies using cells from BM aspirates of MM patients ...
4-oxadiazolyl)]-4-quinolinecarboxamide by virtual screen using a customized version of DOCK4 program with the crystal structure of STAT3. Oral administrations of STX-0119 arrested the growth of human lymphoma cells in a SCC-3 subcutaneous xenograft model through inhibition of STAT3 activity [36]....
ILK is a critical regulator intracellular integrin signaling. Several ILK inhibitors have been developed and evaluated in preclinical studies. Recently, the tripeptides that mimic a fragment of alpha parvin, one of the ILK-interacting proteins, have been generated to interfere with ILK activity [165...