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Home Journal of Hematology & Oncology Article Olutasidenib in combination with azacitidine induces durable complete remissions in patients with relapsed or refractory mIDH1 acute myeloid leukemia: a multicohort open-label phase 1/2 trial Research Open access Published: 16 January 2025 Volume 18, ...
Division of Hematology, The Ohio State University Wexner Medical Center, The James Cancer Hospital, Columbus, OH, 43210, USA Chunhua Song Contributions SG, YH, and ZG conceived the project; SG and YH designed and performed the experiments; SG and YH analyzed data; ZG and CS provided scientific...
RAS isoform mutations exhibit selectivity across various cancers. Specifically, KRAS mutations are most commonly found in solid tumors, particularly in PDAC, CRC, lung adenocarcinoma (LUAD), uterine corpus endometrial carcinoma (UCEC), stomach adenocarcinoma (STAD), and testicular germ cell tumors (TGC...
Mantle cell lymphoma (MCL) is a rare, B cell non-Hodgkin’s lymphoma with highly heterogeneous clinical presentation and aggressiveness. First-line treatment consists of intensive chemotherapy with autologous stem cell transplant for the fit, transplant
2008 ASH Review (New York Medical College, January 31, 2009) Kami J Maddocks and Thomas S Lin* Address: The Ohio State University, Division of Hematology-Oncology, 320 West 10th Avenue, Columbus, OH 43210, USA Email: Thomas S Lin* - thomas.lin@osumc.edu * Corresponding author from ...
Mantle cell lymphoma (MCL) is a rare, B cell non-Hodgkin’s lymphoma with highly heterogeneous clinical presentation and aggressiveness. First-line treatment consists of intensive chemotherapy with autologous stem cell transplant for the fit, transplant
NE: Not estimable NR: Not reached NSCLC: Non-small cell lung cancer NTRK: Neurotrophic tyrosine receptor kinase ORR: Objective response rate OS: Overall survival pCR: Pathologic complete response PD-1: Programmed death-1 PD-L1: Programmed death-ligand 1 ...
NK cells are able to recognize and kill “stressed cells” including cells infected with viruses, allogeneic cells, and tumor cells without prior sensitization in a non-HLA (human leukocyte antigen)-restricted manner. The effector functions in NK cells are regulated through a balance of signals de...
Mantle cell lymphoma is a B cell non-Hodgkin lymphoma (NHL), representing 2–6% of all NHLs and characterized by overexpression of cyclin D1. The last decade has seen the development of many novel treatment approaches in MCL, most notably the class of Br