However, as recognized by the IWG, we feel that the above definition in children may need further refinement. The majority of children will not have undergone splenectomy, and those who have are likely to respond at least transiently, therefore the term refractory in this population may not be...
Morphological CR according to ELN definition [30] after any therapy except for allo-HCT with stable or increasing MRD in two sequential measurements determined by central RT-qPCR and/or NGS constituted the main inclusion criterion (either in peripheral blood (PB) or bone marrow (BM) or both) ...
Clonal hematopoiesis (CH) and secondary malignancy CH and secondary primary malignancies (SPM), have recently garnered significant attention within the medical community [72,73,74,75]. CH encompasses a spectrum of precursor bone marrow malignancies, predominantly comprising clonal hematopoiesis of indeterm...
In addition to this definition guidance and the SAGER guidelines, the resources on this page offer further insight around sex and gender in research studies. Authorship All authors should have made substantial contributions to all of the following: (1) the conception and design of the study, or...
23 It is yet to be determined whether these more aggressive approaches will improve benefit for patients in light of the probable increased toxicity and effect on quality of life as, by definition, patients are asymptomatic. In our study, treatment discontinuation due to intolerability was not ...
the definition of cognitive impairment is a test score ≥ 1.5 SD worse than the mean of a given test’s normative distribution, adjusted for age, sex and education [38]. It is recommended to screen and evaluate the basic cognitive function of the PCNSL patient using the mini-mental sta...
In addition to this definition guidance and the SAGER guidelines, the resources on this page offer further insight around sex and gender in research studies. Author contributions For transparency, we encourage corresponding authors to provide co-author contributions to the manuscript using the relevant ...
Morphological CR according to ELN definition [30] after any therapy except for allo-HCT with stable or increasing MRD in two sequential measurements determined by central RT-qPCR and/or NGS constituted the main inclusion criterion (either in peripheral blood (PB) or bone marrow (BM) or both) ...
and definition of response. The reported predictors of response to subsequent treatments are often inconsistent across different studies. Selection of subsequent treatments is primarily based on individualized patient factors, including age, lifestyle, comorbidities, concomitant medications, response to previous...
myelodysplasia in patients with MDS: bone marrow blast count reduction to <5 %, normalisation of peripheral blood cell counts and lack of dysplasia are required for the definition of CR in MDS according to International Working Group (IWG) 2000 [27], but not for the definition of CR in ...