Genetic diagnosis may also be valuable in workup of gamma chain disorders, where the window for diagnosis by conventional means is relatively small. Confirmation of abnormality in the beta globin chain may be helpful to explore therapeutic interventions. We present 2 conditions whose diagnoses were ...
Newer classes of anti-myeloma agents approved in recent years, including selinexor (an inhibitor of exportin 1), Teclistamab (BCMA-redirected bispecific T cell engager), and belantamab mafodotin (an antibody-drug conjugate targeting BCMA), have reported median PFS between 3.7 to 11.3 months [...
unmet medical need, principally in cancer, infection and immunology, providing a pipeline of assets to larger and emerging companies. By improving the characteristics of existing drug classes to create highly differentiated, novel, best-in-class drugs, Re...
Table 1. The signature genes, encoded proteins, and functions known in the three classes of CRISPR-Cas systems in 2011 (Makarova et al., 2011 [51]). 3. Development of CRISPR-Cas9 Single-Guide RNA-Mediated Gene Editing In 2011, Charpentier met Jennifer Doudna, a biochemist, at a confere...
Table 1 Different classes of drugs presently used to cure PC Full size table Fig. 1 Timeline demonstrating evolution in the treatment regimen for PC Full size image This review intends to provide an overview of PC, considering aspects such as the risk factors, clinical representations, different ...
in mammalian cells, which are categorized into different classes, based on their homology to yeast deacetylases [5]. By inhibiting these enzymes, HDAC inhibitors permit chromatin to assume a more relaxed conformational state, thereby allowing transcription of genes involved in tumor suppression, cell-...
Table 1 Different classes of drugs presently used to cure PC Full size table Fig. 1 Timeline demonstrating evolution in the treatment regimen for PC Full size image This review intends to provide an overview of PC, considering aspects such as the risk factors, clinical representations, different ...
The normal leukocyte counts and the absolute counts of different classes of leukocytes vary with age in children. The total white blood cell count and the ... P Lanzkowsky - 《Manual of Pediatric Hematology & Oncology》 被引量: 1发表: 2008年 加载更多研究...
Knock-out mice for miR-150 at baseline contained higher serum concentrations of Ig classes, especially IgA, likely due to an expansion of B-1 cells [72]. Similarly, mice that were haploinsufficient for c-Myb had fewer mature B cells in the spleen and fewer B-1 cells, consistent with ...