BACKGROUNDHec1 (highly expressed in cancer, kinetochore-associated protein 2) is a coiled-coil protein that has been demonstrated to have a role in M-phase cell cycle progression. It is one of several proteins involved in spindle checkpoint signaling, required for the recruitment of Mps1 kinase...
实验方案 技术支持 货号39-5900 此产品已停产 100 µg Application Created with Sketch. 图:1/1 HEC1 Antibody (39-5900) in WB Western blot analysis of HEK293 cell lysates using Zymed Ms anti-Hec1 (Product # 39-5900).View more 产品信息 ...
Function: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity (PubMed:9315664, PubMed:12351790, PubMed:14654001, PubMed:14699129, PubMed:15062103, PubMed:15235793, PubMed:15239953, PubMed:15548592, ...
英文名称:Anti-HEC1别名:HEC 1; HEC; Highly Expressed in Cancer; Highly expressed in cancer protein; Highly express包装号:G320 产地:中国大陆/进口产品 商标/品牌:Santa、Abcam、MBL、BD、Cell Signaling Technology供应商:田源试剂 TR、新试剂 NR--- 产品详细描述产品介绍:Acts as a component of the ess...
Characterization of a recently synthesized microtubule-targeting compound that disrupts mitotic spindle poles in human cells Article Open access 08 December 2021 Hydroxyethylamine based analog targets microtubule assembly: an in silico study for anti-cancerous drug development Article Open access 28 Dec...
Assay: Metaphase Spindle Photomarking (Figure 2) Number of kinetochores (cells) 57 (29) 60 (24) 27 (8) Poleward microtubule flux (μm/min) 0. 65 ± 0.05 0.50 ± 0.03 0.73 ± 0.07 WT,9A∗; 9D,9A∗ Kinetochore velocity with respect to microtubule lattice (μm/min) 0.76 ± 0....
The cell was microinjected with antibody 9G3, rhodamine-labeled tubulin (MTs shown in red) and Alexa 488-labeled anti-CENP-F antibody (kinetochores and spindle poles shown in green) and imaged by timelapse spinning-disk confocal microscopy. This movie demonstrates the lack of kinetochore ...
Safety belt reeling means with a tightening device comprising a drive which is activated in the event of an incident is provided. The drive is spaced from a belt winding spindle of the belt reeling means and is connectable thereto via a ... ...
Moreover, EGFP-Hec1 expression was found to increase KT-MT attachment stability, providing a molecular explanation for the abnormal spindle architecture and the cytotoxic activity of this modified protein. Consistent with cell culture data, EGFP-Hec1 expression was found to strongly inhibit tumour ...