Hec1 is one of several proteins involved in spindle checkpoint signaling. This surveillance mechanism assures correct segregation of chromosomes during cell division by detecting unaligned chromosomes and causing prometaphase arrest until the proper bipolar attachment of chromosomes is achieved. ...
BACKGROUNDHec1 (highly expressed in cancer, kinetochore-associated protein 2) is a coiled-coil protein that has been demonstrated to have a role in M-phase cell cycle progression. It is one of several proteins involved in spindle checkpoint signaling, required for the recruitment of Mps1 kinase...
英文名称:Anti-HEC1别名:HEC 1; HEC; Highly Expressed in Cancer; Highly expressed in cancer protein; Highly express包装号:G320 产地:中国大陆/进口产品 商标/品牌:Santa、Abcam、MBL、BD、Cell Signaling Technology供应商:田源试剂 TR、新试剂 NR--- 产品详细描述产品介绍:Acts as a component of the ess...
实验方案 技术支持 货号39-5900 此产品已停产 100 µg Application Created with Sketch. 图:1/1 HEC1 Antibody (39-5900) in WB Western blot analysis of HEK293 cell lysates using Zymed Ms anti-Hec1 (Product # 39-5900).View more 产品信息 ...
Next, we sought to further investigate the possible mechanisms responsible for the observed cytotoxic effects. As cells defective for Hec1 function show chromosome segregation and spindle abnormalities,6,17,18,19we analyzed the mitotic phenotypes of SM-treated HeLa cells. Mitotic progression from metaph...
Characterization of a recently synthesized microtubule-targeting compound that disrupts mitotic spindle poles in human cells Article Open access 08 December 2021 Hydroxyethylamine based analog targets microtubule assembly: an in silico study for anti-cancerous drug development Article Open access 28 Dec...
The N-terminal region of Hec1 is important for mediating microtubule binding and for spindle assembly checkpoint (SAC) function by regulating the kinetochore localization of SAC components, such as Mad1 and Mad2 (Ciferri et al., 2007; DeLuca et al., 2003; Hori et al., 2003; Martin-...
The cell was microinjected with antibody 9G3, rhodamine-labeled tubulin (MTs shown in red) and Alexa 488-labeled anti-CENP-F antibody (kinetochores and spindle poles shown in green) and imaged by timelapse spinning-disk confocal microscopy. This movie demonstrates the lack of kinetochore ...
Safety belt reeling means with a tightening device comprising a drive which is activated in the event of an incident is provided. The drive is spaced from a belt winding spindle of the belt reeling means and is connectable thereto via a ... ...
Hec1 is one of several proteins involved in spindle checkpoint signaling. This surveillance mechanism assures correct segregation of chromosomes during cell division by detecting unaligned chromosomes and causing prometaphase arrest until the proper bipolar attachment of chromosomes is achieved...