Summary The histopathological examination of endomyocardial biopsies is an established method to evaluate organ rejection. During the past few years, reports have addressed important issues concerning the grading system of the International Society for Heart and Lung Transplantation (ISHLT). Nevertheless, ...
Johansson L, Johnsson C, Penno E et al (2002) Acute cardiac transplant rejection: detection and grading with MR imaging with a blood pool contrast agent — experimental study in the rat. Radiology 225:97–103 PubMedGoogle Scholar Kober L, Torp-Pedersen C, Carlsen JE et al (1995) A clin...
An algorithm called CRANE (cardiac allograft rejection neural estimator) was developed by one of us (FM) withcolleagues for the tasks of assessment, subtyping, and grading of heart biopsies. The models were trained on thousands of gigapixel whole slide images from the Brigham and Women’s Hospita...
Computer-aided diagnosis, using digitized whole-slide images, has been used to classify the presence and grading of diseases such as brain tumors and breast cancer, and we expect it can be used for prediction of cardiac allograft rejection. In this paper, we first create a pipeline to ...
CRANE is designed to be used in tandem with expert assessment to establish an accurate diagnosis faster, and it can also be used in settings where there may be few pathology experts available. The team trained CRANE for detection, subtyping, and grading oftransplant rejectionusing thousands of pa...
Rejection grade was evaluated using the Billingham grading system (13). Cyclosporin was administered at 2.5 mg/kg. BX471 was administered at 50 mg/kg. N = number of animals, n = number of tissue blocks examined per group. Mean ± S.E. is shown. 1-a p value relative to control oil ...
Individually, cellular rejection and antibody-mediated rejection are well characterized and routinely evaluated in cardiac transplant biopsies. The co-occurrence of both of these rejection patterns in the same biopsy, or “mixed rejection,” is also recognized, although not as well documented in the ...
Fig. 2: The effects of the absence of miR-146a on immune rejection after heart transplantation. AKaplan-Meier analysis of the allograft survival time (log-rank test),n = 6.BAssessment of PR scoring and CAV grading of allografts using H&E staining according to the ISHLT guidelines,n...
Long-term outcome of cardiac allograft vasculopathy: importance of the international society for heart and lung transplantation angiographic grading scale. J Heart Lung Transplant. 2019;38(11):1189–96. Article PubMed Google Scholar Chih S, Chong AY, Mielniczuk LM, Bhatt DL, Beanlands RSB. ...
Blood samples for GEP testing (AlloMap, CareDx, Brisbane, CA, USA) were collected during post-transplant surveillance. The reference standard for rejection status was based on histopathology grading of tissue from endomyocardial biopsy. The area under the receiver operating characteristic ...