Background Antibody-mediated rejection (AMR) is not well understood and remains a significant cause of morbidity and mortality in heart transplant recipients. Some immunosuppressive induction agents have been linked to a higher incidence of AMR, presumably through prompting antibody formation, while ...
rejection: acuterejection: antibody-mediated (ABMR)Gender-difference regarding antibody-mediated rejection (AMR) after heart transplantation has been described, however no study accounted for the presence of preformed donor-specific antibodies (pfDSA), a known risk-factor of AMR, more common among ...
Antibody mediated rejection (AMR) can significantly influence the results of orthotopic heart transplantation (OHT). However, AMR and cellular rejection (CR) coexistence is poorly described. Therefore we performed a prospective pilot study to assess AMR/CR concomitance in endomyocardial biopsies (EMBs...
Heart transplantation is the definitive therapy for eligible patients with end-stage heart failure. However, antibody-mediated rejection (AMR) of a cardiac allograft—a heart from a genetically non-identical donor – is a recognized clinical complication in the management ofheart transplant patientsand ...
To our knowledge this is the first report of a heart transplant recipient becoming HLA sensitised by a pregnancy and suffering acute antibody‐mediated rejection. Pregnancy in a transplant recipient presents a potentially difficult situation where maternal risk, including allograft rejection, has to be ...
followed by the liver. But Mayo Clinicheart transplantteam decided to reverse the order for highly sensitizedpatientsin the hopes that the liver would absorb some of the patient's antibodies, removing them from circulation and lowering the risk of antibody-mediated rejection. The strategy worked, ...
Individually, cellular rejection and antibody-mediated rejection are well characterized and routinely evaluated in cardiac transplant biopsies. The co-occurrence of both of these rejection patterns in the same biopsy, or “mixed rejection,” is also recognized, although not as well documented in the ...
antibody-mediated rejectiondonor-specific antibodykidney transplantationtransplant rejectionPurpose of reviewTo summarize the evidence supporting the negative impact ... C Wiebe,P Nickerson - 《Current Opinion in Organ Transplantation》 被引量: 53发表: 2013年 Role of routine endomyocardial biopsy to monitor...
摘要: Here we report a case wherein both donor-specific and third-party, paternal, HLA class II specific antibodies developed following a spontaneous miscarriage resulting in antibody-mediated rejection in a patient who had undergone an orthotopic cardiac transplant six years earlier....
(474)–Late Antibody-Mediated Rejection Due To De-Novo Donor-Specific Anti-HLA Antibodies in Heart Transplant Recipients: A Cohort of 20 Consecutive Patientsdoi:10.1016/j.healun.2014.01.481G. CoutanceS. OuldamarP. RouvierC. Suberbielle