Our GWAS for heart shape has provided several interesting candidate genes at signals for PCs 1 and 5 which are not reported for other CV traits. For PC1, signals were found nearVEGFAandVEGFB, two members of the PDGF/VEGF growth factor family, which induce proliferation and migration of vasc...
Adherence to diabetes guidelines for screening, physical activity and medication and onset of complications and death. J Diabetes Complications. 2015;29(8):1228–33. Article PubMed PubMed Central Google Scholar Di Lenarda A, Casolo G, Gulizia MM, Aspromonte N, Scalvini S, Mortara A, Alunni...
Ex situ screening of embryonic hearts identified structural heart defects in mutants for genes previously associated with CVD (Stambp, Nxn, Slc25a1, Smo and Shox2) as well as hitherto unassociated candidate genes (Sirt1, Casz1, Wfdc2, Tmem161b, Dnajc18, Zfp503 and Ubr4). These 14 genes...
Just over two weeks ago I suffered from a serious breakdown in my hometown of Portsmouth, thankfully I was with my best friend at the time who is amazing and she has always been there for me. The tears started and wouldn’t stop but it had been a long time coming. Not wanting to s...
Derval N, Steendijk P, Gula LJ et al (2010) Optimizing hemodynamics in heart failure patients by systematic screening of left ventricular pacing sites. The lateral left ventricular wall and the coronary sinus are rarely the best sites. J Am Coll Cardiol 55:566–575 PubMed Google Scholar Sp...
and increase community awareness of this disease. As recommended by the World Heart Federation, The Gambia needs a national RHD registry based on echocardiography screening (including pregnant women), the provision of safe and high quality BPG, and improved access to cardiac surgery in order to ac...
Ex situ screening of embryonic hearts identified structural heart defects in mutants for genes previously associated with CVD (Stambp,Nxn,Slc25a1,SmoandShox2) as well as hitherto unassociated candidate genes (Sirt1,Casz1,Wfdc2,Tmem161b,Dnajc18,Zfp503andUbr4). These 14 genes, all of which ...
Trial oversight was by the Ashford & St Peter’s NHS Trust Research and Development team and was approved by the institutional review board and ethics committee. All patients gave written informed consent prior to enrolment in the study. All authors had access to data and this manuscript for re...
Thus, various methodologies are constantly being developed, some are as simple as an adaptive threshold to detect the IJ segment (Figure 1) [19], or a basic peak detection algorithm applied after back-and-forth transformation between time and frequency domains for signal screening and cleaning [...