JohnG.F. Cleland and JohnY. Yiannakou and KennethE. Gray and RobertJ.D. Winter and S.G. Ball and D.G. Julian and AndrewT. Elder and AndrewD. FlapanThe LancetYiannakou JY, Gray KE, Winter RJ. ACE inhibitors and heart failure. Lancet. 1992 Mar 14; 339 (8794):687–687....
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There is, however, no evidence of either a benefit or harm with statin therapy in patients who have already developed CHF. There are theoretical concerns about statins in CHF (6), and the presence of CHF was an exclusion criterion in all of the landmark statin studies. The relationship ...
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Cardiovascular disease is the leading cause of death and a major cause of morbidity and disability in the United States, with an estimated 6 million people having symptomatic coronary heart disease (CHD).1 Recent studies2-7 have shown that depression and low perceived social support (LPSS) are ...
Interventions Addition of once-daily 10 mg of dapagliflozin or placebo to guideline-recommended therapy. Main Outcomes and Measures The primary outcome was the composite of an episode of worsening HF (HF hospitalization or urgent HF visit requiring intravenous therapy) or cardiovascular death. Results...
RDN increased myocardial expression of acetylcholinesterase (Ache) and muscarinic receptors (Chrm2), decreased circulating and renal NE, but increased myocardial NE content, restoring so autonomic control of the heart. These changes likely explain improvements in survival after RDN in this model. The ...
Under an Elsevier user license open archiveHighlights Abstract Reverse left ventricular (LV) remodeling and recovery of LV function are associated with improved clinical outcomes in patients with heart failure with reduced ejection fraction. A growing body of evidence suggests that even among patients wh...
To be included, patients had to have a hospital admission due to or complicated by worsening heart failure lasting >48 h within the last six weeks; to have persisting symptoms of heart failure, a LV ejection fraction <40%, an LV end-diastolic dimension >30 mm/m (height); and to be ...