Heart Muscle Tissue Engineering: Advantages and Challenges in Cardiac MicrotissuesThe human heart is a complex, multicellular organ with limited regenerative capacity. In vitro modeling of the human heart is not only important to better understand the composition and function thereof, but also to ...
not myocyte infection, explains most myocardial injury findings among patients hospitalized with COVID-19. Immune cell messengers called cytokines circulating through the body could induce heart muscle inflammation. Systemic inflammation could also
Invertebrateanimals have a great variety of liquids, cells, and modes of circulation, though many invertebrates have what is called an open system, in which fluid passes more or less freely throughout the tissues or defined areas of tissue. All vertebrates, however, have a closed system—that ...
Inflammatory response and healing:The damaged area of the heart muscle triggers an inflammatory response. The heart will attempt to repair itself, but the damaged tissue is replaced by scar tissue, which does not contract like healthy heart muscle. This can hinder the heart’s ability to pump ...
A heart attack can cause other abnormalities besides blocking blood flow. For example, sudden cardiac death may occur when the heart's electrical signals become erratic (arrhythmias). When the heart tissue that is responsible for regular electrical stimulus of heart muscle contractions is damaged, th...
Heart: A four-chambered muscle located underneath the breastbone (sternum) of your rib cage. The heart pumps oxygen-rich blood out to the body and oxygen-poor blood to the lungs. Contraction of the heart muscle is often called a beat. Heart rate: Also called the pulse. This is the freq...
the heart muscle is limited (coronary artery disease), a network of tiny blood vessels in the heart that aren't usually open called collateral vessels may enlarge and become active. This allows blood to flow around the blocked artery to the heart muscle, protecting the heart tissue from ...
included for the following: (1) a computed tomography system with an emitter/detector system for scanning of a patient (2) an image processing unit and display unit with computer and a memory for computer program code for simultaneous display of blood circulation of a muscle tissue and a ...
This process, called cardiac remodeling, is particularly evident following myocardial infarction (MI), where the blockage of a coronary artery leads to widespread death of cardiac muscle. Following MI, necrotic tissue is replaced with extracellular matrix (ECM), and the remaining viable cardiomyocytes ...
Interestingly, the specific muscle cross-sectional area appears to be independent of the total EHM diameter if its cross-sectional area exceeds 0.063 mm2. We routinely generate EHM from different reconstitution volumes ranging from 100 to 1000 µl, depending on its utility: tissue repair requires...