143 Occlusion of the venous duct leads to a significant increase in cell proliferation in fetal skeletal muscle, heart, kidneys, and liver and possibly to an increase in expression of IgF1 and 2 and mRNA. These alterations may have a significant long-term influence on metabolism in the growth...
Although it can be difficult to get heart muscle cells to propagate in large numbers, a team of researchers at the University of Minnesota has found a way to use 3D printing and light-induced excitation to create a living heart pump that has broad implications in medicine. Historically, ...
Heart muscle disease, or cardiomyopathy, is a leading cause of mortality and morbidity worldwide [1]. However, it is difficult to obtain cardiomyocytes (CMs) from patients, and they are often not amenable to functional analysis, making it difficult to study heart disease in vitro. While non-...
we review current knowledge on the direct and indirect effects of these amphetamine congeners on the mammalian heart—more specifically, the isolated human heart muscle preparation
1.any of numerous organic molecules constituting a large portion of the mass of every life form, composed of 20 or more amino acids linked in one or more long chains, the final shape and other properties of each protein being determined by the side chains of the amino acids and their chem...
(3D) tissues greatly improves cell–cell communication with more physiological relevance, promoting structural, metabolic, and functional maturation. Engineered tissues can assume various architectures, such as cell sheets119, spheroids120,121and organoids122, muscle strips in the form of rings90,123, ...
This technique, known as electroporation, selectively affects heart muscle cells (cardiomyocytes) while preserving surrounding tissues such as blood vessels, the esophagus, and the phrenic nerve, which could be damaged during thermal ablation procedures like radiofrequency or cryoablation. Some major ...
Smooth muscle cells snRNA-seq: Single-nucleus RNA sequencing ST: Spatial transcriptomics TGF-β: Transforming growth factor vcCOs: Vaschamcardioids VEGF: Vessel endothelial growth factor References Litvinukova M, et al. Cells of the adult human heart. Nature. 2020;588(7838):466–72. ...
2. Themyocardium, also known as myocardial muscle, is the middle and thickest of the heart’s three layers and consists of specialized cardiac muscle tissue. The constant contraction and relaxation of this muscle creates the pumping movement that maintains the flow of blood throughout the body. ...
Cardiovascular diseases such as myocardial infraction (MI) and ischemic heart disease result in heart attack which cause to necrosis of heart muscle thus impair the heart function and lead to mortality. Heart transplantation is the gold standard method for cardiac damages but the donor shortage and ...