Combined use of small animals for research that require higher throughput and genetic modification and large animals for medical translation could greatly accelerate the overall translation of basic research in the field of auditory neuroscience from bench to clinic....
The threshold ranges and averages of age-matched parental strain mice (F1 hybrids, SNV mice) are indicated at the top of the figure as horizontal gray lines. N2 mice with homozygous and heterozygous Mahl genotypes are distinguished by red and blue colors. (C) Chr 10 haplotype analysis of ...
However, operant conditioning is time-consuming and the training ranges from days to months. Thus, ABR- and PPI-based audiograms are more commonly used to test hearing in animals, as these assessments require only few hours to perform without prior training. However, few studies have quantified...
Distortion products also have been observed in signals recorded from the ear canals of humans and animals when the e~r is stimulated by two external tones (Kemp, 1979b; Kemp & Brown, 1983~; Kim, 1980; Kim, Molnar, & Matthews, 1980; Wilson, 1980a; Zurek, Clark, & Kim, 1982). ...
Even though all mammals have initially lived on land, some spend all, or a considerable amount of, their time in water. Under water, at ranges beyond a few meters, sound is a more reliable sensory cue than vision. To find prey such as fish and squid,marine mammalshave evolved acute unde...
Studies of adults, children, and laboratory animals suggest an association between lead exposure and hearing loss. A causal relationship might direct mandated medical surveillance of lead-exposed workers to include audiometric testing. A cross-sectional, computerized dataset was obtained from a private ...
Generally the dosage facilitates an intended purpose for both prophylaxis and treatment without undesirable side effects, such as toxicity, irritation or allergic response. Although individual needs may vary, the determination of optimal ranges for effective amounts of formulations is within the skill of...
Mitochondrial Ca2+ regulates a wide range of cell processes, including morphogenesis, metabolism, excitotoxicity, and survival. In cochlear hair cells, the activation of mechano-electrical transduction and voltage-gated Ca2+ channels result in a large in
Ranges relation between acoustic input and voltage output ranges Full size image Sensor’s EIN and sensitivity greatly vary according to the transduction principle. For example, sensitivity of common electret condenser microphones (ECM), with a 2.5 mm diameter membrane, used in conventional hearing aid...
that ranges from 0 Hz to 1 kHz in 1 s and its mirrored version of 1 kHz to 0 Hz. Between both sweeps, flagella remained 1 s unstimulated (shown as a shorter section in the figure). The flagellar responses to sweeps (middle) were used to extract an “envelope” of the...