MRISpin lockT1ρLiver fibrosisProposed T1ρ pulse sequence design and protocol enabled acquisition of a single slice T1ρ weighted images in a single breath-hold and hence mitigated breathing motion related artifacts. Preliminary results have shown the sensitivity of T1ρ values to changes induced by...
It also allows for quantifying liver iron concentration (LIC) in patients. However, this is an invasive method with significant limitations and possible risks. Magnetic resonance imaging (MRI) and evaluation of the R2* relaxation rate can be an alternative to biopsy for assessing LIC. However, ...
Previously we have discussed the various factors that can lead to the development of IR and subsequently to the development of MAFLD. IR leads to increased lipolysis and subsequent release of free fatty acids (FFA) from adipose tissue to the liver, which is the main contributor to increased de...
Compositional and Functional MRI of Skeletal Muscle: A Review Due to its exceptional sensitivity to soft tissues, MRI has been extensively utilized to assess anatomical muscle parameters such as muscle volume and cros... MT Hooijmans,L Schlaffke,B Bolsterlee,... - 《Journal of Magnetic Resonan...
a full 40% of normal-weight individuals harbor insulin resistance—a sign of chronic metabolic disease—which will likely shorten their life expectancy. Of those, 20% demonstrate liver fat on MRI of the abdomen. Liver fat, irrespective of the rest of body fat, has been shown to be a ...
Radiographic changes appear relatively late in the disease process and so MRI of the stifles (knees) of the four Finn-Dorset clones was undertaken, as MRI is more sensitive in detecting early structural changes60. To minimize the duration of sedation required, MRI scans were taken only of the...
a full 40% of normal-weight individuals harbor insulin resistance—a sign of chronic metabolic disease—which will likely shorten their life expectancy. Of those, 20% demonstrate liver fat on MRI of the abdomen. Liver fat, irrespective of the rest of body fat, has been shown to be a ...
Alcohol dehydrogenase (ADH) activity in stellate cells and the influence of the ADH inhibitor 4-methylpyrazole (4MP) on the response of these cells to ethanol was assessed. Malondialdehyde levels were determined as an indicator of lipid peroxidation. The effect of the antioxidant vitamin E on the...
Frailty was evaluated by body composition using magnetic resonance imaging (MRI) and locomotor abilities measured by the open field test (OFT), one of the oldest and most widely used assays for rodent behavior [23]. Cellular senescence and oxidative stress were assessed by western blotting (WB)...
We also aim to underpin sex-specific differences in metabolic and cardiovascular functional outcomes (fat mass accumulation, metabolic flexibility, arterial stiffness and blood lipid and liver concentrations) in response to the 7-day HFHC diet. Methods Subjects and ethical approval A cohort of young ...