Health technology assessment and price negotiation alignment for rare disorder drugs in Canada: Who benefits?CanadaHealth technology assessmentOrphan drugsRare diseasesBackground:Since 2014, the Canadian Agency for Drugs and Technologies in Health (CADTH), which performs health technology assessments for ...
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…The bill also sets a starting point for Medicare negotiations at 1.2 times the average price of drugs in Australia, Canada, France, Germany, Japan and the U.K.—all of which have some form of socialized health system. …foreign price controls have reduced access to breakthrough treatments....
“Health Canada agrees with the World Health Organization that expired vaccine should not be used and any expired doses should be disposed of safely,” the department said. However, “the shelf-life of vaccines may be extended if scientific evidence is provided to regulatory ...
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Rare disease (RD) management and orphan drug development in India face various hurdles regarding the implementation and adoption of comprehensive policies, lack of dedicated regulatory frameworks, and absence of epidemiological data. Current rare disease
Screening oral drugs for their interactions with the intestinal transportome via porcine tissue explants and machine learning A machine-learning model trained on interactions between oral drugs and intestinal drug transporters obtained by modulating their expression in intact porcine tissue can be used to...
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However, 95% of rare diseases have no treatment and require specialized rehabilitation services to improve patient quality of life. Only 2% of rare diseases benefit from orphan drugs capable of interfering with disease progression; a further 3% rely on established treatments for common or prevalent ...