Head-and-neck squamous cell carcinomaCD34CA-IXNecrosisHuman papillomavirusBackground and purpose The aim of the preDan Ou a bIngrid Garberis cJulien Adam cPierre Blanchard aFrance Nguyen aAntonin Levy aOdile Casiraghi cPhilippe Gorphe dIngrid Breuskin d...
1.1 Cyclin-dependent kinases, inhibitors, and common alterations in head and neck squamous cell carcinoma and glioblastoma multiforme Cyclin-dependent kinases (CDK) are a family of conserved serine/threonine protein kinases. Among the 13 human CDK, some play essential roles in cell cycle regulation ...
Righi PD, Kelley DJ, Ernst R, Deutsch MD, Gaskill-Shipley M, Wilson KM, Gluckman JL. Evaluation of prevertebral muscle invasion by squamous cell carcinoma. Can computed tomography replace open neck exploration? Archives of otolaryngology--head & neck surgery. 1996 Jun:122(6):660-3[PubMed...
However, cancer cell-intrinsic signaling-dependent control of PD-L1 expression remains to be elucidated. Herein, we aimed to identify the let-7 family of microRNAs as candidates that up-regulate tumor cell PD-L1 expression and mediates immune evasion of head and neck squamous cell carcinoma (...
ObjectivesWe tried to clarify the correlation of the expression of CCR7 and CXCR4 with lymph node and distant metastasis.Materials and methodsWe examined expression of CCR7 and CXCR4 in 9 HNSCC cell lines and 25 HNSCC tissues by semi-quantitative RT-PCR and immunohistochemistry study. We examined...
Head Neck 27:415–420 CrossRef Temam S, Koka V, Mamelle G, Julieron M, Carmantrant R, Marandas P, Janot F, Bourhis J, Luboinski B (2005) Treatment of the N0 neck during salvage surgery after radiotherapy of the head and neck squamous cell carcinoma. Head Neck 27:653–658 Cross...
the monovalent 7D12 [31], [33] and the biparatopic 7D12-9G8 [34], specifically targeted the epidermal growth factor receptor (EGFR). With more than 83% of all head and neck squamous cell carcinomas overexpressing EGFR [35], it serves as a promising target in head and neck cancer ...
Concurrent chemoradiation therapy is the current standard of care for patients with locally advanced squamous cell carcinoma of the head and neck. Chemotherapy is given for the duration of radiation therapy unless otherwise stated; definitive radiation doses used are 66-72 Gy (2.0 Gy/fraction; daily...
Skin cancer of the head and neck may involve the parotid gland or parotid lymph nodes either by direct invasion or by lymphatic/hematogenous spread. The most common cutaneous malignancies that spread to the parotid gland are squamous cell carcinoma a
Immune-checkpoint inhibitors (ICIs) are being tested as neoadjuvant therapies in various solid tumours, including in patients with head and neck squamous cell carcinoma (HNSCC), with promising results. Key findings thus far include that this approach is