Hydrogen deuterium exchange (HDX) mass spectrometry (MS) is a powerful tool for studying the dynamics of higher order structure of protein-based therapeutics. The rate of hydrogen-to-deuterium exchange within the amide hydrogen on the backbone of biotherapeutics provides...
Structure of the full-length glucagon class B G-protein-coupled receptor (Q Exactive MS) Haonan Zhang, Anna Qiao, Dehua Yang, Linlin Yang, Antao Dai, Chris de Graaf, Steffen Reedtz-Runge, Venkatasubramanian Dharmarajan, ...
Combination of circular dichroism spectroscopy and size-exclusion chromatography coupled with HDX-MS for studying global conformational structures of peptides in solutionProtein foldingSECHDXCDInsulinGlucagonMisfolding of therapeutic peptides and proteins can lead to numerous issues, ranging in severity, ...
performance, productivity, and usability in a nano-, capillary-, and micro-flow UHPLC systems. TheVanquish Neo UHPLC systemcombines an unrivaled degree of innovation to deliver 24/7 reproducible separations of complex mixtures at maximum performance for a variety of high-...
Structure of the full-length glucagon class B G-protein-coupled receptor (Q Exactive MS) Haonan Zhang, Anna Qiao, Dehua Yang, Linlin Yang, Antao Dai, Chris de Graaf, Steffen Reedtz-Runge, Venkatasubramanian Dharmarajan, ...