The results in tumor growth were only observed when an HFHC diet was administered to the mice, not when they were fed a standard chow diet [41]. Therefore, although the uptake of cholesterol via apoE was blocked, other adipocyte apoE-independent receptors, such as LDL receptor (LDLR) [43...
The ATP-binding cassette transporter A1 (ABCA1), a major reverse cholesterol transporter, is a critical factor in the generation of apolipoprotein E (ApoE) and high-density lipoprotein (HDL) cholesterol. ApoE is the most abundant apolipoprotein in the brain and delivers lipids and cholesterols ...
(cholesterol oleate-3H and phospholipids-14C or triolein-3H and cholesterol-14C) at 37 °C under stirring for 1 h. After this procedure, 250 µL of precipitating reagent (0.2% dextran/0.3 mol/L MgCl2) was added followed by stirring for 30 s and centrifugation for 10 min at 3000 ...
Finally, a strong correlation between non-HDL-C/HDL-C ratio and cholesterol bound to VLDL (r = 0.77, p < 0.001) has been found. Non-HDL-C/HDL-C ratio is associated with the presence of carotid atherosclerosis in post-menopausal women and is strongly correlated to VLDL-C levels. ...
4.4. Cholesterol Efflux J774 mouse macrophage cells were plated and labeled with 2µCi of3H-cholesterol/mL overnight. Cells were then incubated for 6 h in either the absence or presence of cyclic AMP (cAMP) to upregulate ABCA1. ApoB-containing lipoproteins were removed from serum by polyethy...
Cerebrovascular diseases and the subsequent brain hypoperfusion are at the basis of vascular dementia. Dyslipidemia, marked by an increase in circulating levels of triglycerides and LDL-cholesterol and a parallel decrease in HDL-cholesterol, in turn, is
For specific food and dietary compounds (identified in the first scrutiny) the following terms were also applied after the dietary compound name AND: “HDL functionality”; “cholesterol efflux capacity”; “CETP OR cholesterol ester transfer protein”; “PON1 OR paraoxonase 1”; “adhesion ...
HDL particles can be structurally modified in atherosclerotic disorders associated with low HDL cholesterol level (HDL-C). We studied whether the lipidome of the main phosphatidylcholine (PC), lysophosphatidylcholine (LPC) and sphingomyelin (SM) species of HDL2 and HDL3 subfractions is associated...
Decreased high-density lipoprotein cholesterol and serum apolipoprotein AI concentrations are highly correlated with the severity of Alzheimer’s disease. Neurobiol. Aging 2000, 21, 27–30. [Google Scholar] [CrossRef] Shih, Y.H.; Tsai, K.J.; Lee, C.W.; Shiesh, S.C.; Chen, W.T.; ...
Dyslipidemia has become one of the most serious public health problems in the world because of its high prevalence [1,2] and a causal relationship of conditions such as coronary artery disease (CAD) [3], obesity and metabolic syndrome [4]. Low high-density lipoprotein-cholesterol (HDL-C) as...