LDL中的胆固醇容易在血管壁沉积形成斑块导致动脉硬化,HDL中的胆固醇帮助清除血管壁多余胆固醇并运回肝脏代谢。 1. LDL功能分析:LDL负责将胆固醇从肝脏运输到外周组织。当血液中LDL浓度过高时,多余的胆固醇会被氧化并渗入血管内皮,引发泡沫细胞形成和动脉粥样硬化斑块。2. HDL的逆向运输机制:HDL可将外周组织(包括血管壁)...
HDL 携带的胆固醇主要是使之回到肝脏中去,从而得以得到代谢并排除,最后可以达到一个减少胆固醇沉积的作用,提供动脉血管的HDL,血浆胆固醇量其实是减少的。 所以说低密度脂蛋白(LDL)中的胆固醇是“bad cholesterol” ,而高密度脂蛋白(HDL)中的胆固醇是“good cholesterol”。反馈...
LDL-cholesterol versus HDL-cholesterol in the atherosclerotic plaque: inflammatory resolution versus thrombotic chaos. Ann N Y Acad Sci 2012;1254:18-32.Badimon, L. & Vilahur, G. 2012, "LDL-cholesterol versus HDL-cholesterol in the atherosclerotic plaque: inflammatory resolution versus thrombotic ...
Circulating hormones (e.g., estrogen) can be esterified by lecithin-cholesterol acyltransferase (LCAT) on HDL and readily incorporated into HDL. Esterified HDL hormones can also be transferred to LDL through CETP activity. The delivery of esterified HDL hormones to recipient cells was found to be...
Spertus, J. A., Jones, S. R., & Lipoprotein Investigators Collaborative (LIC) (2015). HDL cholesterol subclasses, myocardial infarction, and mortality in secondary prevention: the Lipoprotein Investigators Collaborative. European heart journal, 36(1), 22–30.https://doi.org/10.1093/eurheartj/...
Which is worse triglycerides or LDL? LDLis known as the “bad” cholesterol because having too much LDL may cause a buildup of plaque in your blood vessels. Triglycerides are also a type of fat found in your blood. High triglycerides, low HDL, and/or high LDL numbers can increase your ...
HDL is usually requested with other tests, either with cholesterol or as part of a lipid profile, including LDL and triglycerides. The combination of total cholesterol and HDL is very useful for screening for the risk of heart disease.
A cholesterol test generally determines 4 distinct numbers: Total cholesterol, LDL, HDL, and triglycerides. Cholesterol being fat, it is not soluble in water. So it cannot circulate freely in the blood. But, the fact is that nature has devised a way to make water-soluble cholesterol, and tr...
LDL cholesterol: Low-density lipoproteins (LDL) are the so-called "bad" type of cholesterol, according to theAmerican Heart Association(AHA). While LDL cholesterol isn't bad on its own, if a person has too much LDL, it can join with other substances like calcium and formfatty depo...
Cholesterol and triglyceride concentrations in serum-plasma pairs Clin Chem, 23 (1977), p. 60 Google Scholar 15. Lindgren F.T., Jensen L.C. The isolation and quantitative analysis of serum lipoproteins Nelson G.J. (Ed.), Blood Lipids and Lipoproteins: Quantitation, Composition and Metabolism,...