Just knowing your total cholesterol isn't enough. Not only does the total cholesterol number need to be normal but HDL and LDL numbers need to be in the appropriate range. Normal total cholesterol associated with a high LDL may still increase the risk ofheart diseaseand stroke.Triglyceride leve...
ApoA-1是HDL的结构蛋白,而ApoB是LDL,VLDL等非HDL的结构蛋白,近年随着对这两种蛋白的研究的深入,发现ApoB比LDL跟心血管病的关系跟密切,有建议用ApoB取代LDL作为心血管病的风险指标。 ApoA-1是HDL的前体,ApoA-1由肝脏细胞和小肠的肠细胞产生,是一种没有脂肪没有胆固醇的蛋白质,ApoA-1需要结合另一种称为“ATP...
TG 是这些脂蛋白存在的标志,然而降低 TG 的治疗不一定能给糖尿病患者带来心血管益处,这可能是由于 LDL-C 和载脂蛋白 B 水平的增加抵消了降低 TG 带来的益处。 因此,未来旨在降低 TG 的试验中应同时减少 RC、非 HDL-C 和载脂蛋白 B。...
2021 年发表在 European heart journal 的一项研究 [4],纳入了来自 ARIC、MESA 和 CARDIA 队列共 17532 名基线时没有动脉粥样硬化心脏病(ASCVD)的参与者,中位随访为 18.7 年,该研究发现较高的 RC 与 ASCVD 发病风险升高有关,且独立于 LDL-c 和 apoB。 当RC 升高时,无论 LDL-c 是否升高,ASCVD 发病风险...
Sex: Males often have higher levels of LDL than females. After menopause, a woman's LDL levels can also increase.5 Weight: People who are overweight or obese are at increased risk of high cholesterol. Sedentary lifestyle: Lack of physical activity can increase the risk of overweight and obes...
240 mg/dL and overHigh A cholesterol chart: Total, LDL, HDL, Triglycerides, VLDL It would be more convenient for everybody to interpret their cholesterol test results if only they could provide just one number as a result. Unfortunately, there exist multiple cholesterol types, as well as vari...
Three classes of agents that raise HDL-C in addition to lowering low-density lipoprotein (LDL) and/or plasma triglycerides have been tested. Although trial results with fibrates and niacin produced variable outcomes, meta-analyses supported the beneficial effects of both, although it was not ...
Regarding the SARS- CoV-2 infection, low LDL-C, HDL-C and triglyceride (TG) levels have been described to be associated with an increasing infection s everity6, and a role for these lipids in immune mechanisms has been s uggested13. Low lipid levels during the infection have ...
Purified HDL, but not LDL, significantly enhanced inactivation of factor Va by activated protein C (APC) and protein S (69). HDL has also been shown to scavenge anionic phospholipids, thereby abolishing their pro-coagulant properties (70). Whether these anti-thrombotic effects apply to humans ...
HDL3 was isolated from six newly diagnosed CAD subjects prior to and 1 year after combination therapy with niacin (a potent HDL-cholesterol elevating drug) and atorvastatin (which markedly lowers LDL-cholesterol levels). After digesting HDL proteins with trypsin, we analyzed the resulting peptide mi...