Inactivation of the mouse homologue of the Huntington disease gene (Hdh) results in early embryonic lethality. To investigate the normal function of Hdh in the adult and to evaluate current models for Huntington disease (HD), we have used the Cre/loxP site-specific recombination strategy to ...
1994. The murine homologues of the Huntington disease gene (Hdh) and the alpha- adducin gene (Add1) map to mouse chromosome 5 within a region of conserved synteny with human chromosome 4p16.3. Genomics 22:198- 201.Nasir, J., Lin, B., Bucan, M., Koizumi, T., Nadeau, J. H., ...
(HD) is a dominant neurodegenerative disorder caused by expansion of a CAG repeat in the gene encoding huntingtin, a protein of unknown function. To distinguish between ''loss of function'' and ''gain of function'' models of HD, the murine HD homolog Hdh was inactivated by gene targeting....
The identification of the Huntington's disease (HD) mutation as a CAG/polyglutamine repeat expansion enabled the generation of transgenic rodent models and gene-targeted mouse models of HD. Of these, mice that are transgenic for an N-terminal huntingtin fragment have been used most extensively ...
We further reveal that YTHDF2 downregulation also occurs as part of the host protein kinase R response to a VacV shutoff mutant and that this downregulation of YTHDF family members functions to enhance interferon-stimulated gene expression to create an antiviral state. 展开 关键词: YTHDF ...
Huntington’s disease (HD) is an autosomal dominant neurodegenerative disease that is caused by the expansion of a polyglutamine (polyQ) stretch within Huntingtin (htt), the protein product of the HD gene. Although studies in vitro have suggested that the mutant htt can act in a potentially dom...
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Reverse transcription polymerase chain reaction (RT-PCR was conducted for partial sequence cloning of Hdh-SMP5 using muscle tissue cDNA, gene-specific forward and reverse primer, and GoTaq®DNA polymerase (Promega, Madison, WI, USA). The gene-specific primer used in the present study was desi...
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Například ServerCrashProcedures u osamocených tabulek může být potřeba opravit chybu po vygenerování chybějících souborů s informacemi o tabulce.Kopírovat hbase --config /etc/hbase/conf hbck -j ~/hbase-operator-tools/hbase-hbck2/target/hbase-hbck2-1.x.x-...