it did not include supplemental testing to confirm the positive anti-hcv results. we think this is a golden opportunity for a healthy debate and to remember that a high rate of false-positive results occurs in low-prevalence populations (range, 15%-60%). in the study by mcginn et al, ...
Introduction:The use of a signal-to-cut-off ratio has been recommended by the Centre for Disease Control and Prevention to determine the need for further validation using a supplemental test. In this study, we aimed to determine the optimal true-positive signal-to-cut-off ratio for the ABBOTT...
HCV-Ab检测HCV-Ab是机体由于HCV的刺激而产生的蛋白质,HCV-Ab检测是一种间接检测,也是目前最常用于HCV临床筛查的检测方法之一,但存在一些不足:窗口期长,易发生漏诊;无法区分现症感染和既往感染;免疫缺陷症患者可能会出现假阴性结果; 在HCV-Ab抗体水平极低的人群中,HCV-Ab检测会出现比较高的假阳性几率 [1] 。因...
参考文献: [1]Contreras AM, Tornero-Romo CM, Toribio JG, et al. Very low hepatitis C antibody levels predict false-positive results and avoid supplemental testing. Transfusion. 2008;48:2540-2548. [2] Kesli R, Polat H, Terzi Y, et al. Comparison of a...
On the contrary, anti-HCV positive test result in high-risk population or a situation where HCV infection is suspected, it is likely to be true positive and confirmation with HCV RNA test will be significant. Quantitative HCV RNA test and genotyping should be performed if therapy is considered...
Therefore, anti-HCV ELISA screening and nucleic acid detection strategy can accurately diagnose the current infected patients; however, it cannot distinguish the false positive results of antibody screening. KEYWORDS: Hepatitis C virus;Intravenous drug users;Recombinant immunoblot assay;Nucleic acid test ...
routine screening, we detected whether they had an HCV-related visit to an HCV-related department during their follow-up period (Supplemental Table 2). As expected, patients detected as HCV seropositive had significantly more visits to the Gastroenterology and Infectious Disease departments (p < ....
Supplemental Digital Content is available in the text The impact of sex on metabolic alterations in individuals with hepatitis B virus (HBV) or hepatitis C virus (HCV) infection remains elusive. A community-based study was performed to a... JH Hu,MY Chen,CT Yeh,... - 《Medicine》 被引量...
Assessments Study oversight Screening, on-treatment, and posttreatment study assess- ments are outlined in Supplemental Table 1. Unless otherwise specified, genotyping and HCV RNA and This study was approved by an independent ethics com- mittee at each participating site and was conducted in ...
The humanization and affinity maturation of the murine antibodies AP33 and mu5B3 to generate MRCT10.v362 and hu5B3.v3, respectively, are described in detail in Supplemental Materials. MRCT10.v362 and hu5B3.v3 had ~ 2-fold increased binding affinity to soluble versions of E2 (sE2661) fr...