Injection drug use has been associated with the highest risk of HBV and HCV co-infection, compared to other risk groups (1,2) . Because of their common mode of transmission, dual infection with HBV and HCV occurs in at-risk patients....
1. HBV再激活定义:我国最新的《慢性乙型肝炎防治指南》[5]将HBV再激活(HBV reactivation)定义为乙型肝炎表面抗原(hepatitis B surface antigen,HBsAg)阳性/ HBV核心抗体(hepatitis B virus core antibody,抗-HBc)阳性,或HBsAg阴性/抗-HBc阳性...
近年来我国HIV、HBV和HCV流行发生了一定的变化,2015年和2023年新诊断HIV感染者合并HBV感染率分别为13.8%和9.0%,合并HCV感染率分别4.8%和2.4%,2023年合并感染率均显著低于2015年。 在我国不同地区HIV感染者合并HBV和HCV感染率差异性大,下降程度也存在差异(图1)。在...
艾滋病和病毒性肝炎都是全球重要的公共卫生问题,由于有相似的传播途径,HBV和HCV感染率在HIV感染者中高于非HIV感染者的水平,且合并感染情况在静脉吸毒和男-男同性性行为人群更为常见。 近年来我国HIV、HBV和HCV流行发生了一定的变化,2015年和2023年新诊断HIV感染者合并HBV感染率分别为13.8%和9.0%,合并HCV感染率分别4...
The replication of one virus may dominate the other and antiviral therapeutic strategies should target the dominant virus. Standard interferon-α or pegylated interferon is usually the treatment of choice for HBV/HCV and HBV/HDV coinfection. Adding ribavirin or lamivudine may benefit HBV patients co...
除此之外,《中国艾滋病诊疗指南(2021年版)》和《DHHS指南(2021年版)》均建议,HIV/HBV/HCV三重感染患者使用的ART方案必须有抗HBV活性,推荐使用TAF(TDF)/FTC(3TC)为基础的ART方案[3,4]。 药物间相互作用(DDI) 患者同时使用DAA和ART方案,需要考虑药物不良反应的累加和药物代谢的相互影响。
BACKGROUND: The HIV, HBV and HCV viruses are the major public health concern all over the world including Nepal. The aim of the study is to determine the rate of HBV and HCV co-infections in patients with HIV infection. METHODS: The study cohort included 218 consecutive HIV infected patient...
结论:HIV感染者中,HCV和HBV感染率均高于一般人群,静脉注射毒品和经血液传播是HCV与HIV共感染的高危因素,静脉注射毒品和性传播是HBV和HIV共感染的高危因素,应针对相应的高危人群采取有效干预措施。【关键词】感染率,丙型肝炎病毒,乙型肝炎病毒,艾滋病毒PrevalenceofhepatithCvirusandhepatitisBvirusinfectioninHIVpositive...
In this work, we have shown that hepatitis C virus (HCV) and hepatitis B virus (HBV) can coexist in the same hepatocyte using double fluorescent in situ hybridization in liver biopsy samples from patients with chronic HCV infection with occult HBV infection. Digital image analysis of hybridizatio...
Infectivity of HCV/HIV-1 co-infection is reduced to undetectable levels by microwave irradiation Full size image Microwave irradiation of contaminated syringes abrogates HCV as well as HIV-1 infectivity Full size image Inactivation of HCV and/or HIV-1 in contaminated drug preparation filters after mi...