given that more than half of all full-length HIV-1 ge- nomes in the database are recombinant (20,21), the combinatorial melting assay may be a valu- able tool to screen multiple genomic regions of HIV for recombinant strains. Acknowledgments The authors gratefully acknowledge the generos- ...
ScreeningDried blood spotPeople who use drugsLinkage to careHCV treatmentBackground The burden of hepatitis C virus (HCV) infection among people who use drugs (PWUDs) is considerable. We aimed to screen for HCV infection using the fingerstick dried blood spot (DBS) test and to describe the ...
AJS, LF, BZ, and AB have no competing interests to disclose. SR has served as an invited speaker forAbbott.BM has served as an advisor forMerck, Abbott, Janssen, Gilead, Roche, Bristol-Myers SquibbandBoehringerand has received grants fromRocheandGilead.PB has served as an advisor forMerck...
The powder mixture can be wet-granulated with a binder such as syrup, starch paste, acadia mucilage or solutions of cellulosic or polymeric materials, and forcing through a screen. As an alternative to granulating, the powder mixture can be run through the tablet machine and the result is ...
Blood donors who test reactive on HCV enzyme immuno assay (EIA) but nonreactive on HCV recombinant immunoblot assay represent a continuing challenge for transfusion services. Should they be dropped from the donor pool because their donations test unspecifically positive in the HCV-EIA screen, even ...
The proportion of tow HCV infections associated with blood or blood product transfusion has been markedly reduced due to pharmaceutical advances and widespread use of sensitive serologic and RNA detection assays used to screen blood donors, however, a large cohort of aging, chronically infected persons...
Chronic hepatitis C virus (HCV) infection is associated with an increase in hepatic steatosis and a decrease in serum levels of total cholesterol, low-density lipoprotein cholesterol (LDL) and apolipoprotein B (apoB), the main protein constituent of LDL and very low-density lipoprotein (VLDL). ...
BMC Public Health 2014, 14:3 http://www.biomedcentral.com/1471-2458/14/3 RESEARCH ARTICLE Open Access Prevalence of hepatitis C in a Swiss sample of men who have sex with men: whom to screen for HCV infection? Axel J Schmidt1,2*, Luis Falcato3, Benedikt ...
A rapid diagnostic test (RDT) (Alere Determine™ HIV-1/2) was used for the qualitative detection of anti-HIV-1/2 antibodies, whereas an enzyme-linked immunosorbent assay (ELISA Genscreen™ ULTRA HIV Ag-Ab) was employed to detect the viral antigens in the plasma of donors. For HBV, ...
In a chemical screen, we identified K67, a small compound that inhibits the interaction between phosphorylated p62-peptide and Keap1. Our modelling studies indicate that K67 binds to a pocket within Keap1 that is involved in the interactions with Nrf2-ETGE, Nrf2-DLGex and phosphorylated p62 ...