Our findings suggested that the feasibility of cMAP combining microarray gene expression profile may help identify a potential drug that possibly will reverse the effect of 5FU-induced resistance.doi:10.1016/j.gmbhs.2012.04.001Ailun Heather Tseng...
基因差异表达倍数大于2.其中包括促凋亡基因TRAIL,CASP10,TNFB,BIM和DIVA,亦有抗凋亡基因BCL2,HIAP1,NAIP等.[结论]在HCT116细胞中,SSD可能通过TRAIL激活死亡受体途径引发细胞凋亡过程.%[Objective]To explore the effect of saikosaponin D(SSD) ...
Gene expression profile outlined that caspase-3, BAX, and P53 genes were strongly upregulated relative to their control, while BCL2, MMP1, and CDK2 were effectively down regulated assuming the activation of the apoptotic pathway. Flow cytometry technique revealed that compound 7 stimulated cell ...
A major driver of the biology of hypoxic tumours is the transcription factor HIF-1α(Carmeliet et al, 1998), which is responsible not alone for altered gene expression, but also may contribute to cancer progression and the development of a phenotype more refractory to therapy (Harris, 2001). ...
(B) Representative FACS profile for SC-560-induced alterations to the cell-cycle distribution following treatment of HCT116 (p21+/+) cells with vehicle alone (control) or with 50 or 100 M SC-560 for 24 h. (C) SC-560 treatment induced the upregulation of p21CIP1 in HCT116 (p21+/+)...
DNA Profile (STR): HCT 116细胞Amelogenin: X,Y CSF1PO: 7,10 D13S317: 10,12 D16S539: 11,13 D5S818: 10,11 D7S820: 11,12 THO1: 8,9 TPOX: 8,9 vWA: 17,22 Cytogenetic Analysis: The stemline chromosome number is near diploid with the modal number at 45 (62%) ...
基因差异表达倍数大于2.其中包括促凋亡基因TRAIL,CASP10,TNFB,BIM和DIVA,亦有抗凋亡基因BCL2,HIAP1,NAIP等.[结论]在HCT116细胞中,SSD可能通过TRAIL激活死亡受体途径引发细胞凋亡过程.%[Objective]To explore the effect of saikosaponin D(SSD) on cell apoptosis gene profile in colon carcinoma HCT116 cells. ...
Methods:Tandem mass tag (TMT)-based proteomics analysis was performed to detect the differential protein expression in Ftx-overexpressing and Ftx-silenced HCT116 cells. The differentially expressed proteins were classified and characterized by bioinformatics analyses, including gene ontology (GO) annotation...
Expression profile analyses of human HCT-116 colon cancer cell line before and after serum inductionGENE -AMSTERDAM-YinH.YanZ.LiangY.LiuB.Q.
The results confirmed that cells lacking the GPX4 gene (GPX4 KO) should be more susceptible to ferroptosis after erastin treatment. However, the decrease in cell viability was not as significant as we initially assumed. Based on the lipid peroxidation markers profile and RT-qPCR gene expression ...