摘要 目的探讨HCT—CI评分系统预测老年急性髓系白血病(AML)患者化疗风险及在预后判断中的价值。方法回顾性分析2000年1月至2010年12月收治的116例年龄〉160岁AML患者的临床资料,116例患者均接受以阿糖胞苷为...展开更多 Objective To investigate the value of the HCT-CI score in chemotherapy risk assessment and...
The median OS in patients with an HCT-CI score ≤3 was 87 months versus 11.5 months in those with a score >3 (log-rank, p=0.0046, Fig1). 2-yr NRM rate for patients with HCT-CI score ≤3 and >3 was 47% and 71%, respectively (p=0.01, Fig2). Hazard ratio for overall ...
The evaluation of the HCT-CI impact after DRI stratification was able to show a significant difference in outcome showing better survival for pts with low DRI score and low HCT-CI score as expected (table 1.b). Discussion Refined DRI score and HCT-CI score predict survival after haplo-HSCT...
Regarding the 2-year overall survival (OS), the flexible HCT-CI score categories were also associated with the highest predictive HR. In conclusion, our single-center study suggests that the flexible HCT-CI is a good predictor of 2-year NRM and survival after an allo-RIC....
A negative correlation was found between HCT-CI score and total hospital days as well as days spent in hospital after discharge from initial transplant hospitalization, implying that the higher the score the less time spent in the hospital after transplant (Table 1). Ho...
Most patients had hematological malignancies (73%) and a low HCT-CI score (72%). The non-relapse mortality and survival were predicted according to the score.#This is one of the few studies to evaluate the HCT-CI in adults with HLA-matched donors in a developing country and our findings...
Using an HCT-CI score of 3, 18 patients scoring ≥ 3 developed 44 grade 3-5 toxicities, while 19 patients with a score < 3 developed 20 grade 3-5 toxicities ( p = .002). ANCOVA multivariate analysis demonstrated that an HCT-CI score of 3 can predict the number of grade 3-5 ...
Most patients had HCT-CI score <2 (71.8%). Secondary AML was diagnosed in 23.5% of patients, and most patients had intermediate (32.9%) or adverse (37.6%) ELN cytogenetic risk. Fifty-five (58.8%) patients achieved CR after induction. Median OS reached 16.0 months [95% CI: 11.0-21.00]...
Comorbidities were obtained by retrospective chart review and scored according to the HCT-CI score. Results: 150 patients (median age 40) were includdoi:10.1016/j.bbmt.2007.12.295T. KovacsovicsB. ParkB. Hayes-LattinA. DunnP.T. Curtin
257: Validation of the hematopoietic cell transplantation-comorbidity index (HCT-CI) for non-relapse mortality (NRM) and survival after matched unrelated donor SCTBackground: The HCT-CI is a recently developed comorbidity score which has been adapted to hematopoietic stem cell transplantation, with ...