The efficacy of Hydroxychloroquine (HCQ) as post-exposure prophylaxis (PEP) for the prevention of COVID-19 was contentious. In this randomized control double-blind clinical trial, asymptomatic individuals with direct contact with laboratory-confirmed COV
Gr 2 rash (n = 1) due to HCQ. No Gr 4/5. Dose reduction: 70% for SOR, 0% for HCQ. PD analysis on the 3 responders show favorable immune profile changes (increase in cytotoxic T cells and decrease T Regs). Conclusions: SOR/HCQ had a better response rate (25%) than historically...
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Patch testing is used to identify allergens that may be causing outbreaks of contact dermatitis - a localized rash or irritation of the skin where allergen(s) came in contact. Patch tests are used in patients with dermatitis to find out whether their skin condition may be caused by, or...
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In multivariate analysis, patients with symmetrical proximal muscle weakness or an abnormal CHAQ score were less likely to be on HCQ therapy; whereas patients with any rash (malar erythema, Gottron's sign, heliotrope rash, V-sign or shawl sign), calcinosis or arthritis had a hi...