troponins C, I, and T, and titin--several HCM-related mutations have been identified. Most are missense mutations, permitting the biosynthesis of a full-size protein with a substitute amino acid at one or another position
In patients with hypertrophic cardiomyopathy (HCM), the first-in-class cardiac myosin inhibitor mavacamten (MyoKardia), on top of medical therapy, significantly improved hemodynamics, functional capacity, and symptoms when compared with patients who received placebo, according to results of the EXPLORE...
thus preventing any longitudinal studies on the time course of the disease. In 1996 the first transgenic mouse model encoding for the HCM mutation R403Q had been reported13and several additional HCM mice have been generated since then. However, these rodent models ...
In Global Payroll for China, an iterative trigger must be defined for each table containing retroactive or segmentation triggers. • Segmentation Tells the system to segment a period or element. PeopleSoft Global Payroll delivers a full segmentation and an element segmentation event with Global ...
Bristol Myers Squibb (NYSE: BMY) today announced that the European Commission (EC) has approved CAMZYOS® (mavacamten, 2.5 mg, 5 mg, 10 mg, 15 mg capsules) for the treatment of symptomatic (New York Heart Association...
Each absence case can be viewed in detail, with all relevant documents attached, such as medical certificates. ADVICE absence management assists with the coordination of first time-, follow up-, return- and level related meetings, to assure all important topics are discussed. It also provides no...
Through the many acquisitions in the service segment, IFS has expanded its footprint in field service management software to include the full range of company sizes (through the WorkWave acquisition that added smaller company reach to the portfolio) as well as state-of-the-art functionality like...
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In one of our recent surveys of more than 350 implementations of Oracle Autonomous Database in Western Europe and the US, our research shows 75 have already gone live in the first five months of 2020, compared with 140 for the full year of 2019, suggesting that despite the pandemic there ...
by Shelley Wood Shelley Wood is the Editor-in-Chief of TCTMD and the Editorial Director at CRF. She did her undergraduate degree at McGill… Read Full Bio Sources Disclosures Comments American Heart Association. AHA names top heart disease and stroke research advances of 2020. Published on: ...