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2A). Transwell invasion assays demonstrated that the number of invasion cells were reduced in HCC cells overexpressing Flag-TH (Fig. 2B, C). In addition, the wound-healing assay demonstrated that the overexpression of TH suppressed the migration of HCC cells (Fig. 2D, E). To further confirm...
Student's t-test was used to compare the means. For both tests, a value of P,0.05 was considered statistically significant. The Kaplan–Meier product limit estimator was used to graph overall survival. Univariate analysis was performed with the log-rank test. Cox proportional hazards regression ...
Student's t-test, one-way ANOVA, or Pearson chi-square test were utilized in this study to determine differences in all inter- group variables. The criterion for meaningful difference for all analyses was P < 0.05. Results DNA methylation characteristics and differentially methylated regions ...
Student's t-test was used to compare the means. For both tests, a value of P<0.05 was considered statistically significant. The Kaplan–Meier product limit estimator was used to graph overall survival. Univariate analysis was performed with the log-rank test. Cox proportional hazards regression ...
The data were presented as mean ± SD, *P < 0.05, **P < 0.01, by Student's t-test proliferation decreasing in the CDK6 shRNA cells com- pared to the circ-ZEB1.33 shRNA cells, this result might indicate that there might be other mechanism besides the circ-ZEB1.33/miR-...
Statistical analysis were performed by two-tailed Student’s t-test. Full size image We subsequently investigated the regulatory role of DUSP22 on the pathological progression of NASH to HCC in DUSP22HepKO and DUSP22HepOE mice treated with DEN (25 mg/kg; at 2 weeks old) and a 24-...
Student's t-test or one-way ANOVA (one-way analysis of variance) followed by the LSD post hoc test was conducted to compare the differences between two groups or more than two groups, respectively, with SPSS (SPSS 18.0; SPSS Inc., Chicago, IL, USA). A P value<0.05 was considered to...
GraphPad Prism 8.0 software (San Diego, CA, USA) or IBM SPSS 24.0 software (IBM, New York, NY, USA) was used for statistical analysis. Unpaired Student’st-test was used for comparisons of two groups. Comparisons between more than two groups were performed using ANOVA with Tukey’s or Bo...
Backgrounds: Abnormal metabolism is the hallmark of hepatocellular carcinoma. Targeting energy metabolism has become the major focus of cancer therapy. The natural product, sanguinarine, displays remarkable anti-tumor properties by disturbing energy home