2]. Although the diagnosis and treatment techniques have improved significantly in recent years, the long-term survival rate among the HCC patients is still very low, this is mostly because of the fast metastatic property and higher rate of recurrence [3,4]. Therefore, finding an alternate ther...
S6K phosphorylation and c-Myc were elevated, but the LC3-II/LC3-I ratio remained high (Figure 4E). This was markedly different from Atg7Δhep liver in which p62 was strongly induced and autophagy was completely blocked, but phospho-S6K was not elevated. p62-Induced tumors were positive for ...
AFP, alpha-fetoprotein; ALBI, albumin–bilirubin; ALBI-1, ALBI-2 and ALBI-3: ALBI grades 1, 2, and 3; HR, hazard ratio; OS, overall survival; Ram, ramucirumab. Results were consistent in the separate cohort of patients in REACH with Child-Pugh class B, with similarly worse prognosis ...
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