AT is critical for determining the hepatic lipid fluxes in fasting/fed states. In fasting, AT lipolysis is the main contributor to hepatic lipid influx: in the context of AT dysfunction and (central) obesity, fatty acids (FA) turnover is elevated (due to increased fat mass and cell-autonomo...
However, considering SLD solely a consequence of obesity is an oversimplification, since it can also develop in subjects with normal Body Mass Index (BMI): adipose tissue (AT) dysfunction, rather than AT mass, is likely to be the main driver of its development and progression [8], together ...