AT is critical for determining the hepatic lipid fluxes in fasting/fed states. In fasting, AT lipolysis is the main contributor to hepatic lipid influx: in the context of AT dysfunction and (central) obesity, fatty acids (FA) turnover is elevated (due to increased fat mass and cell-autonomo...
Last, we provide a critical overview of current state of the art (pre-clinical and clinical evidence) regarding mechanisms of action and therapeutic efficacy of candidate SLD treatment options, and their potential to interfere with SLD/HCC pathophysiology by diverting lipids away from the liver ...