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The importance of HCC codingLori Zimmerman
The Cas9 stable-expressing MHCC97L cells (MHCC97L-Cas9) were established by lentiviral transduction of Cas9 coding sequence into the genome of cells. MHCC97L was a gift from Fudan University (Professor Z.Y. Tang, Shanghai, China). The expression of Cas9 protein was confirmed by a Cas9-spe...
Among solid tumors, hepatocellular carcinoma (HCC) emerges as a prototypical therapy-resistant tumor. Considering the emerging sorafenib resistance crisis in HCC, future studies are urgently required to overcome resistance. Recently noncoding RNAs (ncRNAs) have emerged as significant regulators in signalli...
Regarding the efficacy of drugs, it must be considered that the two main classes act as inhibitors of enzymatic cascades or receptors involved in carcinogenesis. However, these mechanisms, although important from a molecular point of view, are not the only ones responsible. This involves an ...