Well, getting the right letters together still matters, and in the healthcare world, three letters to pay close attention to are HCC. Those letters stand forHierarchical Condition Category (HCC)coding. They are at the heart of calculating patients’ risk scores, predicting healthcare expenditures,...
We found that the expression of METTL1 and WDR4 protein levels were significantly elevated in HCC samples relative to normal liver tissue samples (Additional file 1: Figure S1). The qRT-PCR results showed that METTL1 and WDR4 were significantly upregulated in HCC cells (Fig. 1a), with the...
long noncoding RNAsPD‐L1Background Growing evidences have been revealing that long noncoding RNAs are vital factors in oncogenesis and tumor development. Among them, cancer susceptibility candidate 11 (CASC11) has displayed an impressively essential role in various kinds of cancers including ...
In the current study, we have demonstrated for the first time that cell competition promotes drug resistance development in HCC by facilitating the dominant growth of lenvatinib-resistant HCC cells. Mechanistically, the hyperactivation of BNIP3-mediated mitophagy in lenvatinib-resistant HCC cells promotes...
Accumulating studies have implicated the role of long non-coding RNAs (lncRNAs) in the pathogenesis of hepatocellular carcinoma (HCC) through the regulating transcription and mRNA stability. A recent report has linked Rac GTPase-activating protein 1 (RACGAP1) to the early recurrence of HCC. The ...
The role of long noncoding RNA (lncRNAs) had been demonstrated in different types of cancer, including hepatocellular carcinoma. This study was intended to investigate the role of lncRNA small nucleolar RNA host gene 5 (SNHG5) in HCC proliferation and th
(1). These small particles of 40 to 5,000 nm in diameter are released by several cells into the extracellular matrix. While they were previously considered as a means to discard cellular metabolic waste, recently emerging evidence suggest that they are essential players in cell-to-cell ...
Values are means+SEM, *p < 0.05 and ***p < 0.001, compared to control group. Two-tailed unpaired T-Test was used for statistical analysis by SPSS 19.0 software Full size image Discussion Despite the progress in understanding carcinogenesis and therapeutic approaches, the prognosis of ...
refractory to the treatment, provide additional rational for the neoadjuvant use of immunotherapy. This study aimed to explore the “neoadjuvant” therapy of HCC, which means the tumors must be clearly and definitely “resectable”; in BCLC staging system, resection/(ablation/transplantation) is only...
. Western blotting was performed to determine the distribution of β-catenin proteins in the nucleus and cytoplasm in SK-hep-1 after cells were knockdown (F) and overexpression (G) of USP39. All the data are representative of at least three independent experiments and presented as the means...