Mechanistically, ACSL4 plays a dual role in HCC cells by promoting lipid accumulation under nutrient-rich conditions and enhancing lipid catabolism and energy production to support cell survival during glucose deprivation. The transcriptional upregulation of ACSL4 by CEBPA mediates the pro-survival ...
5H). Following this, the dual luciferase reporter assay revealed that EGR1 had a repressive impact on the luciferase activity of the original PFKL promoter, but it had no influence on the luciferase activity of the P2 mutant in the PFKL promoter (Fig. 5I). The aforementioned experimental ...
BCL-2 proteins, which are known for their dual role in apoptosis and autophagy, have also been demonstrated to be a poor predictor for prognosis and play a key role in chemoresistance in HCC32,33,34,35. Other studies have demonstrated that p53 inhibitor and AKT activator depressing the expres...
Sorafenib (SF) is the first drug approved by the Food and Drug Administration (FDA) for the treatment of advanced HCC and remains one of the most commonly used drugs in systemic therapy for hepatocellular carcinoma. It is an effective targeted chemotherapy drug that can inhibit angiogenesis, prol...
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c Dual-luciferase assay results indicating the activity of the RBM15 gene promoter in HBx-oe and NC cells. d Western blot results showing the knockdown efficiency of si-RBM15 in HCC cells. e, f MeRIP-qPCR (e) and qRT‒PCR (f) results showing the m6A level and expression of cFAM210...
Shaaban MA, Kamal AM, Faggal SI.Design, synthesis, and biological evaluation of new pyrazoloquinazoline derivatives as dual COX-2/5-LOX inhibitors.Arch Pharm (Weinheim). 2020;353:e2000027. https://doi.org/10.1002/ardp.202000027. Article CAS PubMed Google Scholar Liu L, Zhang P, Zhang ...
EditShare, a technology leader in intelligent scale-out storage, AQC and media management solutions, announced today that the South Korean based global electronics telco and IPTV powerhouse LG U has selected EditShare solutions to produce and distribute the highly popular SBS Medianet music program, ...
An increasing evidence supports that cell competition, a vital selection and quality control mechanism in multicellular organisms, is involved in tumorigenesis and development; however, the mechanistic contributions to the association between cell compet
Androgen receptor variant 7 (AR-V7), an AR isoform with a truncated ligand-binding domain, functions as a transcription factor in an androgen-independent manner. AR-V7 is expressed in a subpopulation of hepatocellular carcinoma (HCC), however, its role(s