cell proliferation, cell survival, and tumorigenesis. When autophagy is defective, p62 is accumulated, while active autophagy leads to p62 degradation48. In addition, p62 is also a receptor protein for ubiquitin degradation
This trial was approved by the Ethics Committee of Shandong Cancer Hospital and Institute (SDZLEC2022-021-01). It was conducted in accordance with the International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use and the Declaration of Helsinki. All patients provid...
Cell competition drives the dominant growth of lenvatinib-resistant cells in HCC To characterize the biological behavior conferred by lenvatinib resistance of HCC cells, we established successfully the lenvatinib-resistant HCC cell strain (Huh7R; IC50 = 40.91 μM) with the resistance characteri...