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此外,该检测方法在不同肝病病因中保持了其诊断效能[45-46]。 2. 非编码 RNA(noncoding RNAs,ncRNAs):ncRNAs的主要成分是 microRNA(25～30 bp)和长非编码 RNA(>200 bp),它们是不翻译成蛋白质的 RNA 分子,是参与染色质改变、D...
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RNA-binding proteinQKILong non-coding RNAEGOTBackground RNA-binding proteins are revealed to play important roles during the progression of hepatocellular carcinoma (HCC). However, the regulatory mechanisms of RNA-binding protein Quaking (QKI) in the expression and role of long non-coding RNAs (...
identified a long non-coding RNA (SMIM30) that binds to ribosomal protein S6 (RPS6), which regulates cell proliferation and migration to promote HCC devel- opment [39]. Han et al. found that adhesive junction- associated protein 1 (AJAP1) oversubscription restrained tumor initiation and ...
a Those coding for both HBV and HCV fall into the group with HBV. Rate of MALO and Its Components The incidence rate (95% CI) of MALO was lower in PLWH (5.1/1000 PY, 95% CI 4.2–6.1) compared to patients without HIV (13.1/1000 PY, 95% CI 12.9–13.3). The rate of MALO was ...
and adapters were subsequently ligated to the resulting double-stranded cDNA fragments. The coding regions of the transcriptome were then captured from this library using sequence-specific probes to create the final library. Paired-end 150 bp sequencing was conducted using the Illumina Novaseq6000 pl...
An increasing evidence supports that cell competition, a vital selection and quality control mechanism in multicellular organisms, is involved in tumorigenesis and development; however, the mechanistic contributions to the association between cell competition and tumor drug resistance remain ill-defined. In...
and adapters were subsequently ligated to the resulting double-stranded cDNA fragments. The coding regions of the transcriptome were then captured from this library using sequence-specific probes to create the final library. Paired-end 150 bp sequencing was conducted using the Illumina Novaseq6000 pl...
To achieve overexpression of EGR1 or PFKL, the coding sequences (CDs) of EGR1 or PFKL were inserted into the MCS domain of the expression plasmid. Prof. Ni Tang (Key Laboratory of Molecular Biology on Infectious Diseases, Chongqing Medical University) supplied the LentiCRISPR-v2, pMD2.G, ...