ATphC crystal structure in both an apo (open—orange) and TPA-bound (closed—blue) conformation have been superimposed (SSM superposition of domain 1) in ICM-Pro. The protein surfaces for each of the two states are shown as meshes and coloured according to their respective structure (open—o...
Here, a 2.6 resolution crystal structure of the N-terminal sensing domain of the anaerobic periodontopathogen Porphyromonas gingivalis HcpR is presented. The protein has classical features of the regulators belonging to the FNR-CRP family and contains a hydrophobic pocket in its N-terminal sensing ...
The three typical domains of the members of the CRP/FNR family are boxed according to the structure of DNR regulator from Pseudomonas aeruginosa [65]. Black shading of the amino acid residues corresponds to 100% of similarity. 3.2. Phylogenetic analyses of HcpR sequences To understand the ...
Lewis M. Brown, Koji Uchida, Owen A. O’Connor, Brent R. Stockwell*. Imidazole Ketone Erastin Induces Ferroptosis and Slows Tumor Growth in a Mouse Lymphoma Model. Cell Chemical Biology, 2019; 26(5):623-633.e9. doi...
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Electronic structure analyses were also conducted to reveal the role of catalysts in C O2 adsorption and hydrogenation, with detailed computing methods shown in the Supplemen- tary information. The pristine graphene was modeled as a monolayer flake of finite size with 50 carbon atoms, and its...
If two pos sibilities are just alike simpliciter (if that is possible) then no information 88 O. Lewis whatsoever can eliminate one but not both of them. So if there is a kind of information-namely, phenomenal information-that can eliminate pos sibilities that any amount of ...
结合气相色谱结果及Gryglewicz[2]、Shaikh[10]、Tundo[11]和王庆印[12]提出的催化机理,作者提出反应机理如下:咪唑阴离子作为一种很好的亲核试剂进攻DMC,生成CH3OCOIm和甲氧基阴离子咪唑离子液体[Bmim]OCH3,[Bmim]OCH3与异辛醇发生质子交换得到[Bmim]OC8H16和甲醇,甲醇被及时蒸出,促进平衡移动,得到的[Bmim]O...
2.3. Activity to Kv and TRPV1 Channels: Electrophysiological Assay and Comparative Structure Analysis In order to characterize HCRG21 functionally, recombinant HCRG21 was, at a concentration of 10 µM, tested for its activity against an 8 voltage-gated potassium channels (Kv1.1–Kv1.6, hERG,...
Thus, differences in the ability of ciBoNT/E HP and BoNT/E Hc proteins to elicit neutralizing antibodies might be traced to their unusual structure. The BoNT/F Hc vaccine also displays less effective potency than other serotypes. This may also be the result of protein structural differences ...