Every year, more than 600 thousand persons will develop hepatocellular carcinoma (HCC) worldwide. Sixty percent of all HCCs in Asia and Africa are related to chronic infection with the hepatitis B virus (HBV) compared to only 20% of HCC cases in Europe, Japan and USA. Surveillance of ...
Its flagship product, Liocyx-M004, is the world's first FDA-approved TCR-T cell therapy targeting HBV-related hepatocellular carcinoma (HCC) to enter international multicenter Phase 2 clinical trials. The therapy has...
SINGAPORE Hepatitis B and liver cancer are significant global public health challenges. Hepatitis B virus (HBV) infection is a leading risk factor for liver cancer, particularly HCC. Globally, an estimated 296 million people live ...
Patients with hepatocellular carcinoma (HCC) have poor long-term survival following curative resection because of the high rate of tumor early recurrence. Little is known about the trajectory of genomic evolution from primary to early-recurrent HCC. In this study, we performed whole-genome sequencing...
Importantly, the first effects of mass vaccination have been detected in Taiwan with significant reduction of HBV-related HCC in vaccinated children [6]. Although high viral load is known to increase the risk of developing HCC [7], the risk remains elevated in HBsAg-negative HBV infection and ...
It was concluded that Arg-1 can improves the ability to detect HBV + HCC patients when compared with HepPar-1. When, both markers being positive, the specificity and PPVs of this combination were fairly higher. Concurrent use of these two proteins may be one of the best HCC detection...
Hepatitis B virus (HBV) is one of the major risk factors of hepatocellular carcinoma (HCC). Increasing evidence indicates that microRNA (miRNA)-mRNA axis is involved in HCC. However, a comprehensive miRNA-mRNA regulatory network in HBV-related HCC is still absent. This study aims to identify...
by Engineering (a) Phase transition diagrams between CHB, LC, and HCC due to chronic HBV infection, including the situation of acute-on-chronic liver failure (ACLF) and death from HCC. Each blue ball represents a patient with the corresponding liver disease. When the ball crosses the peak, ...
The outcome of liver surgery in metabolic syndrome-related hepatocellular carcinoma (MetS-HCC) still needs to be evaluated. We aim to clarify the outcomes following liver resection in patients with MetS-HCC compared those with hepatitis B virus-related HCC (HBV-HCC). Methods All the consecutive ...
Our research indicated that the inhibitory effects of colchicine on HBV and HBV-related HCC depend on the selective autophagic degradation of HBc. Thus, colchicine is not only a promising therapeutic strategy for chronic hepatitis B but also a new treatment for HBV-related HCC....