Chronic infection with hepatitis B virus (HBV) is a risk factor for hepatocellular carcinoma (HCC). This occurs through a complex, multistep process that likely involves both viral and host factors, as well as interactions with other cancer risk factors. In 1996, a model was proposed for HBV...
Figure 2.NF-κBp65 was upregulated in HBV-associated hepatocellular cancer. This research clarifies a vital mechanism of aerobic glycolytic metabolic reprogramming in the carcinogenesis of HBV-related HCC, and reveals that...
Additionally, qRT-PCR revealed that only hsa-miR-212-5p (P = 0.0072), hsa-miR-1250-5p (P = 0.0235), and hsa-miR-1248 (P = 0.0480) exhibited significant differential expression between non-HCC and HCC cohorts. Consequently, we shortlisted hsa-miR-212-5p, hsa-miR-1250-5p,...
HBV‐related HCCHCClncRNASNPBackground Long nonヽoding RNA (lncRNA) plays an essential role in hepatitis B virus‐related hepatocellular carcinoma (HBV‐related HCC) occurrence and development. Single nucleotide polymorphism (SNP) may affect HBV‐related HCC susceptibility by altering the function of...
Patients with hepatocellular carcinoma (HCC) have poor long-term survival following curative resection because of the high rate of tumor early recurrence. Little is known about the trajectory of genomic evolution from primary to early-recurrent HCC. In this study, we performed whole-genome sequencing...
Its flagship product, Liocyx-M004, is the world's first FDA-approved TCR-T cell therapy targeting HBV-related hepatocellular carcinoma (HCC) to enter international multicenter Phase 2 clinical trials. The therapy has...
Assessing liver function in patients with HBV-related HCC:a comparison of T 1,mapping on Gd-EOB-DTPA-enhanced MR imaging with DWI. Ding Y,Rao S X,Chen C,et al. European Radiology . 2015Ding Y;Rao SX;Chen C;.Assessing liver function in patients with HBV-related HCC:a comparison of T...
Hepatocellular carcinoma (HCC) represents the largest proportion in liver cancer [1]. HCC incidence rates vary globally, with the majority of HCC cases occurring in East Asia and sub-Saharan Africa, due to the high prevalence of Hepatitis B virus (HBV) and hepatitis C virus (HCV). The ...
Hepatitis B virus (HBV) is one of the major risk factors of hepatocellular carcinoma (HCC). Increasing evidence indicates that microRNA (miRNA)–mRNA axis is involved in HCC. However, a comprehensive miRNA–mRNA regulatory network in HBV-related HCC is still absent. This study aims to identify...
This study evaluates the diagnostic performance of potent biomarker-based panels composing of serological AFP, miR-122 and circulatingpromoter mutations for screening HBV-related HCC.promoter mutations (C228T and C250T) and miR-122 expression were assessed in the plasma samples from 249 patients with ...