[5] CRISPR/Cas9-mediated p53 and Pten dual mutation accelerates hepatocarcinogenesis in adult hepatitis B virus transgenic mice. Sci Rep. 2017 Jun 5;7(1):2796. [6] A Mouse Model of Inducible Liver Injury Caused
A simple automatic calibration routine for the HBV model. Nordic Hydrology 28, 153±168.Lindstrom, G., 1997: A simple automatic calibration routine for the HBV model. Nordic Hydrol. 28(3), 153- 168.Lindstrom, G. (1997), A simple automatic calibration routine for the HBV model, Nord. ...
从下图的预测的p蛋白结构与HIV对应结构域的对比来看，两者间是如此的相似。这为ETV、TDF等抗HIV药物用于慢性乙肝的临床抗病毒治疗提供了结构基础。原文图3. Superpositions of HBV P models. (a) HBV genotype B RT domain from the catalytic core model (yellow) versus the HBV RT domain model (purple) fro...
The model is analyzed. We give some useful biological results to show that the disease-free equilibrium is both locally and globally asymptotically stable when the basic reproduction number is less than unity. Our findings of this paper strongly recommend a combination of effective treatment and ...
引证本文:SU Y, ZHU YF, TIAN QY, et al. In vitro cell model and mouse model of HBV cccDNA[J]. J Clin Hepatol, 2019, 35(6): 1205-1211. (in Chinese) 苏瑜, 朱园飞, 田青右, 等. HBV cccDNA的体外细胞模型和实验小鼠模型[J]. 临床肝胆...
引证本文:SU Y, ZHU YF, TIAN QY, et al. In vitro cell model and mouse model of HBV cccDNA[J]. J Clin Hepatol, 2019, 35(6): 1205-1211. (in Chinese) 苏瑜, 朱园飞, 田青右, 等. HBV cccDNA的体外细胞模型和实验小鼠模型[J]. 临床肝胆病杂志, 2019, 35(6): 1205-1211....
海河南拒马河流域水文特性及HBV模型的应用
FIGURE 1. Model of in vivo phenotype of precore (PC) PC and basal core promoter (BCP) variants according to findings by Uchida and colleagues. Human liver chimeric mice were infected with PC/BCP variant or wild-type HBV and the liver phenotype analyzed by different approaches 来源：片警实验...
These rcccDNA could be generated in large quantity, served as cccDNA surrogates both in vitro and in vivo, and so provide a new useful model for HBV research and drug discovery. In the present study, based on the Cre/loxP-mediated recombinant HBV rcccDNA system (Qi et al., 2014), we ...
Abstract Co-infection with hepatitis B (HBV) and D virus (HDV) is associated with the most severe course of liver disease. Interferon represents the only treatment currently approved. However, knowledge about the impact of interferons on HDV in human hepatocytes is scant. Aim was to assess the...