最近,童舒平、张继明和夏宁邵团队在《Gut》发表”Naturally occurring 5′preS1 deletions markedly enhance replication and infectivity of HBV genotype B and genotype C”,发现慢乙肝患者来源的HBV病毒前S1蛋白具有缺失突变,缺失突变可...
During chronic HBV infection, a direct relation exists between serological detection of anti-HBs and anti-HBc antibodiesand quantity and function of their respective specific B cells. However, the transcriptomic analysis performed in HBsAg- and HBcAg-specific B cells suggests additional roles of HBV-...
Hepatitis B virus (HBV) persistently infected about 250 million people worldwide, and a curative treatment remains an unmet medical need. Among many approaches to treat chronic hepatitis B (CHB), therapeutic vaccines have been developed for two decades,
在另一个实施例中,中和针对特定hbv基因型例如基因型d的抗体可以具有比参考抗体针对相同基因型的ic50值高不超过50、10、9、8、7、6、5、4、3或2倍或小于或等于其的ic50值,其中参考抗体选自由以下项组成的组:bc1.187、bv4.115、bc8.159、bv6.172、bc1.229、bc8.111、bc1.128、bc3.106、bc1.180、bv4.104、bc8.104...
Chronic hepatitis B virus (HBV) infection induces chromosomal hyperploidy (including aneuploidy and polyploidy) and chromosomal instability in hepatocytes, which is one of the main causes of primary hepatocellular carcinoma (HCC). Although hepatocytes can regulate polyploidization of chromosomes under ...
实用肝脏病杂志2011年6月第l4卷第3期JClinHepatol,June2011.V0lJ14No.3慢性乙型肝炎患者HBV核心区与聚合酶区特异性CTL表位变异分析许智慧任晓强刘妍李晓东王耀戴久增徐东平·l79·著·【摘要】目的比较急性乙型肝炎、慢性乙型肝炎与慢性重型乙型肝炎患者HBVC蛋白和Pol蛋白特异性CTL表位变异的差异,以探讨乙型肝炎重症化...
studyofHBVvector.hygromycin—resistantpackagingcell linewasdevelopedthatallowsencapsidationofplasmidsintoHBVparticles.MetlmdsFreeofpaekagingsignal, HBVgenomewasinsertedintoplasmidpMEP4,whichexpressestheHBVstructuralproteinsincludingcore,pol andpreS/Sproteins.HepG2celllineswereenl’ployedtotransfectwiththeconstruct....
许多研究证明了 AAV8载体在体内表达具有良好的肝嗜性(Gao G, et al. New recombinant serotypes of AAVvectors. Curr Gene Ther. 2005 Jun ;5 (3): 285-97. Davidoff AM, et al. Comparison ofthe ability of adeno-associated viral vectors pseudotyped with serotype 2,5,and 8capsid proteins to ...
(1) undergoing nucleation upon nucleus entry; (2) serving as template for production of all HBV RNAs and proteins; (3) deriving virions capable of infecting tree shrew, and subsequently producing viral mRNAs, proteins, rcccDNA and infectious virions. As an example to develop anti-cccDNA drugs...
同济医科大学博士学位论文HBV/WHVS基因杂合子表达质粒系统的建立及功能分析姓名:***学位级别:博士专业:传染病学指导教师:**亮2000.5.1同济医科大学博士生毕业论文(2000)HBV,WHVS基因杂合子表达质粒系统的建立及功能分析博士研究生导师郑昕杨东亮教授中文摘要目的:构建HBV/WHVS基因杂合子表达质粒系统,了解H13sAg“a”...