Quantitative assay of HBsAg (QAHBsAg) in chronic hepatitis B, especially in evaluation of anti-viral treatment and endpoint prediction has gradually gain the international recognition. Study indicated that serum HBsAg level 1) were correlated with serum HBV DNA and intrahepatic cccDNA amount...
Emilia HadziyannisDimitrios VassilopoulosStephanos J. HadziyannisSpringer NatureCurrent Hepatology ReportsHadziyannis E, Vassilopoulos D, Hadziyannis S. Quantitative HBsAg titer as predictor of response to therapy. Curr Hepat Rep 2009; 8: 169-72....
因此,研究者认为,治疗中的生物标志物预测指标较基线指标更优,预测72周时HBsAg消失的最佳预测指标为第8周的qHBsAg<70 IU/mL。 文献来源:Seng Gee Lim, Wah Wah Phyo, Joanna Zhi Jie Ling, et al. Comparative biomarkers for HBsAg loss with...
81. Liu, Y. P. & Yao, C. Y. Rapid and quantitative detection of hepatitis B virus. World J. Gastroenterol. 21, 11954–11963 (2015). 82. Chen, J., Zhao, S. S., Liu, X. X., Huang, Z. B. & Huang, Y. Comparison of the eficacy of tenofovir versus tenofovir plus entecavir ...
一个是定性(qualitative),一个是定量(quantitative) 。HBVDNA定性的注重于HBVDNA的存在,它通常可以测到低于100copies/ml的病毒存在,定性通常只给阴性、阳性的结果。定量的着重于HBV DNA量存在的多少。通常用于定量的极限在0.1-5 pg/ml之间。国外常用 fg/ml 为单位。copies/ml 比 fg/ml, pg/ml 单位更小。关于...
Lim SG, Phyo WW, Ling JZJ, et al. Comparative biomarkers for HBsAg loss with antiviral therapy shows dominant influence of quantitative HBsAg (qHBsAg)[J]. Aliment Pharmacol Ther, 2020. 往期内容请点击 【期刊导读】HBV RNA需联合HBsAg / HBcrAg指标才可更好预测 HBsAg清除率和持续应答率 ...
[4] Tseng TC, Kao JH. Clinical utility of quantitative HBsAg in natural history and nucleos(t)ide analogue treatment of chronic hepatitis B: new trick of old dog. Journal of gastroenterology 2013; 48:13-21. [5] Tseng TC, Liu CJ, Y...
HBsAg concentrations down to 0.05 mg/ml can be measured by a quantitative immunoelectrophoresis. By a quantitative radioimmunoassay, HBsAg concentrations from 0.001 mg to 1 mg/ml can be measured.doi:10.1111/j.1423-0410.1980.tb02360.xR. Vranckx...
[14] Tseng TC, Kao JH. Clinical utility of quantitative HBsAg in natural history and nucleos(t)ide analogue treatment of chronic hepatitis B: new trick of old dog [J]. J Gastroenterol, 2013, 48(1):13-21. DOI: 10.1007/s00535-012-0668-y. ...
文献来源:Seng Gee Lim, Wah Wah Phyo, Joanna Zhi Jie Ling, et al. Comparative biomarkers for HBsAg loss with antiviral therapy shows dominant influence of quantitative HBsAg (qHBsAg). Aliment Pharmacol Ther. 2020 Nov 7.