Depletion of LDB1, TAL1 and KLF1 in K562 cells using RNA interference resulted in a specific downregulation of MYB expression while leaving HBS1L levels unaffected, demonstrating that the erythroid TFs occupying the intergenic enhancers are required for MYB expression. Using chromosome conformation ...
产品别名 Anti-HBS1L antibody produced in rabbit EF-1a HBS1 HSPC276 ERFS DKFZp686L13262 基本信息 NACRES NA.41 General description【一般描述】 This gene encodes a member of the GTP-binding elongation factor family. It is expressed in multiple tissues with the highest expression in heart and sk...
It is expressed in multiple tissues with the highest expression in heart and skeletal muscle. The intergenic region of this gene and the MYB gene has been identified to be a quantitative trait locus (QTL) controlling fetal hemoglobin level, and this region influnces erythrocyte, platelet, and ...
BackgroundThis gene encodes a member of the GTP-binding elongation factor family. It is expressed in multiple tissues with the highest expression in heart and skeletal muscle. The intergenic region of this gene and the MYB gene has been identified to be a quantitative trait locus (QTL) controll...
It is expressed in multiple tissues with the highest expression in heart and skeletal muscle. The intergenic region of this gene and the MYB gene has been identified to be a quantitative trait locus (QTL) controlling fetal hemoglobin level, and this region influnces erythrocyte, platelet, and ...
The risk allele was also associated with reduced HBS1L expression, but this was less marked (1.9- to 2.4-fold). In addition, we interrogated our previously published gene expression data set derived from haemopoietic colonies of MPN cases17. MYB expression in ET was significantly lower in JAK2...
Common alleles within the three haplotype blocks are associated with HbF expression, with block 2 (24 kb) accounting for the majority of the variance [3]. In this study, of the three genotyped SNPs (rs2838451, block 1; rs4895441 and rs9399137, block 2), only rs4895441 was significantly...
BackgroundThis gene encodes a member of the GTP-binding elongation factor family. It is expressed in multiple tissues with the highest expression in heart and skeletal muscle. The intergenic region of this gene and the MYB gene has been identified to be a quantitative trait locus (QTL) controll...
EXPRESSIONHAPLOTYPECELLSClonal proliferation in myeloproliferative neoplasms (MPN) is driven by somatic mutations in JAK2, CALR or MPL, but the contribution of inherited factors is poorly characterized. Using a three-stage genome-wide association study of 3, 437 MPN cases and 10, 083 controls, we ...
Conclusions Both HMIPs rs11759553 and rs9399137 were significant polymorphisms among thalassaemia carriers co-inherited with Filipino β°-deletion and α3.7 deletion carriers. Both HMIPs demonstrate higher expression of HbF level.doi:10.1016/j.mgene.2020.100769...